Spinal cord injury: pathophysiology, treatment strategies, associated challenges, and future implications

K Venkatesh, SK Ghosh, M Mullick… - Cell and tissue …, 2019 - Springer
Axonal regeneration and formation of tripartite (axo-glial) junctions at damaged sites is a
prerequisite for early repair of injured spinal cord. Transplantation of stem cells at such sites …

Antioxidant therapy in oxidative stress-induced neurodegenerative diseases: Role of nanoparticle-based drug delivery systems in clinical translation

A Ashok, SS Andrabi, S Mansoor, Y Kuang, BK Kwon… - Antioxidants, 2022 - mdpi.com
Free radicals are formed as a part of normal metabolic activities but are neutralized by the
endogenous antioxidants present in cells/tissue, thus maintaining the redox balance. This …

Polyphenols as a versatile component in tissue engineering

X Gao, Z Xu, G Liu, J Wu - Acta biomaterialia, 2021 - Elsevier
The fabrication of functional tissue or organs substitutes has always been the pursuit of
goals in the field of tissue engineering. But even biocompatible tissue-engineered scaffolds …

Effects of polyphenols on oxidative stress, inflammation, and interconnected pathways during spinal cord injury

S Fakhri, F Abbaszadeh, SZ Moradi… - Oxidative medicine …, 2022 - Wiley Online Library
Despite the progression in targeting the complex pathophysiological mechanisms of
neurodegenerative diseases (NDDs) and spinal cord injury (SCI), there is a lack of effective …

Alzheimer's disease and green tea: epigallocatechin-3-gallate as a modulator of inflammation and oxidative stress

V Valverde-Salazar, D Ruiz-Gabarre… - Antioxidants, 2023 - mdpi.com
Alzheimer's disease (AD) is the most common cause of dementia, characterised by a
marked decline of both memory and cognition, along with pathophysiological hallmarks …

The green tea polyphenolic catechin epigallocatechin gallate and neuroprotection

AR Khalatbary, E Khademi - Nutritional neuroscience, 2020 - Taylor & Francis
Epigallocatechin gallate is the most abundant composition of the tea catechins and is
thought to be responsible for the majority of biological activity of green tea extracts such as …

Polyphenols targeting oxidative stress in spinal cord injury: current status and future vision

F Islam, S Bepary, MH Nafady, MR Islam… - Oxidative Medicine …, 2022 - Wiley Online Library
A spinal cord injury (SCI) occurs when the spinal cord is deteriorated or traumatized, leading
to motor and sensory functions lost even totally or partially. An imbalance within the …

Research progress in use of traditional Chinese medicine for treatment of spinal cord injury

Y Lu, J Yang, X Wang, Z Ma, S Li, Z Liu… - Biomedicine & …, 2020 - Elsevier
Background Spinal cord injury (SCI) is a serious central nervous system disorder caused by
trauma that has gradually become a major challenge in clinical medical research. As an …

Mussel-inspired adhesive hydrogels for local immunomodulation

C Xie, Y Li, X Guo, Y Ding, X Lu, S Rao - Materials Chemistry Frontiers, 2023 - pubs.rsc.org
The important function of the immune system is to protect the body from foreign pathogens
and tumor cells, and to participate in the process of tissue repair and anti-tumor activity to …

The importance of natural antioxidants in the treatment of spinal cord injury in animal models: an overview

A Coyoy-Salgado, JJ Segura-Uribe… - Oxidative Medicine …, 2019 - Wiley Online Library
Patients with spinal cord injury (SCI) face devastating health, social, and financial
consequences, as well as their families and caregivers. Reducing the levels of reactive …