Chronic wounds

V Falanga, RR Isseroff, AM Soulika… - Nature Reviews …, 2022 - nature.com
Chronic wounds are characterized by their inability to heal within an expected time frame
and have emerged as an increasingly important clinical problem over the past several …

Wound healing: cellular mechanisms and pathological outcomes

HN Wilkinson, MJ Hardman - Open biology, 2020 - royalsocietypublishing.org
Wound healing is a complex, dynamic process supported by a myriad of cellular events that
must be tightly coordinated to efficiently repair damaged tissue. Derangement in wound …

Flavonoids as potential wound-healing molecules: Emphasis on pathways perspective

N Zulkefli, CNM Che Zahari, NH Sayuti… - International journal of …, 2023 - mdpi.com
Wounds are considered to be a serious problem that affects the healthcare sector in many
countries, primarily due to diabetes and obesity. Wounds become worse because of …

[HTML][HTML] The human skin microbiome

AL Byrd, Y Belkaid, JA Segre - Nature Reviews Microbiology, 2018 - nature.com
Functioning as the exterior interface of the human body with the environment, skin acts as a
physical barrier to prevent the invasion of foreign pathogens while providing a home to the …

Self-healing polysaccharide-based injectable hydrogels with antibacterial activity for wound healing

BD Zheng, J Ye, YC Yang, YY Huang, MT Xiao - Carbohydrate polymers, 2022 - Elsevier
Because the wound is difficult to heal, repeated bacterial infection will lead to complex
clinical problems. Therefore, it is necessary to find an effective method to strengthen the …

Biomaterials releasing drug responsively to promote wound healing via regulation of pathological microenvironment

H Li, B Li, D Lv, W Li, Y Lu, G Luo - Advanced Drug Delivery Reviews, 2023 - Elsevier
Wound healing is characterized by complex, orchestrated, spatiotemporal dynamic
processes. Recent findings demonstrated suitable local microenvironments were …

Skin microbiota–host interactions

YE Chen, MA Fischbach, Y Belkaid - Nature, 2018 - nature.com
The skin is a complex and dynamic ecosystem that is inhabited by bacteria, archaea, fungi
and viruses. These microbes—collectively referred to as the skin microbiota—are …

Bacterial–fungal interactions: ecology, mechanisms and challenges

A Deveau, G Bonito, J Uehling… - FEMS microbiology …, 2018 - academic.oup.com
Fungi and bacteria are found living together in a wide variety of environments. Their
interactions are significant drivers of many ecosystem functions and are important for the …

The prevalence of biofilms in chronic wounds: a systematic review and meta-analysis of published data

M Malone, T Bjarnsholt, AJ McBain… - Journal of wound …, 2017 - magonlinelibrary.com
The presence of biofilms in chronic non-healing wounds, has been identified through in vitro
model and in vivo animal data. However, human chronic wound studies are under …

Engineering a sprayable and elastic hydrogel adhesive with antimicrobial properties for wound healing

N Annabi, D Rana, ES Sani, R Portillo-Lara, JL Gifford… - Biomaterials, 2017 - Elsevier
Hydrogel-based bioadhesives have emerged as alternatives for sutureless wound closure,
since they can mimic the composition and physicochemical properties of the extracellular …