Background—Chagas disease remains a significant public health issue and a major cause
of morbidity and mortality in Latin America. Despite nearly 1 century of research, the …

Autoimmunity occurs when the immune system recognizes and attacks host tissue. In
addition to genetic factors, environmental triggers (in particular viruses, bacteria and other …

Background: Chagas disease (CD) is a neglected tropical disease, endemic in Latin
America, but due to migration and environmental changes it has become a global public …

Chagas disease, caused by the protozoan Trypanosoma cruzi, is endemic in Latin America
and affects ca. 10 million people worldwide. About 30% of Chagas disease patients develop …

The role of interleukin 10 (IL-10) and gamma interferon (IFN-γ) on the development of
pathology in human Chagas' disease was investigated. Two categories of patients, low and …

Chagas disease, caused by the infection with T rypanosoma cruzi, is endemic in all L atin A
merica. Due to the increase in population migration, C hagas disease has spread worldwide …

An inflammatory response is essential for combating invading pathogens. Several effector
components, as well as immune cell populations, are involved in mounting an immune …

Heart lesions of rheumatic heart disease (RHD) patients contain T-cell clones that recognize
heart proteins and streptococcal M peptides. To functionally characterize heart-infiltrating T …

Chagas disease (CD) is caused by the infection with the protozoan haemoflagellate
Trypanosoma cruzi. This disease is still a great menace to public health, and is largely …

Infection by the protozoan Trypanosoma cruzi causes Chagas disease cardiomyopathy
(CCC) and can lead to arrhythmia, heart failure and death. Chagas disease affects 8 million …