The therapeutic potential of carbon monoxide

R Motterlini, LE Otterbein - Nature reviews Drug discovery, 2010 - nature.com
Carbon monoxide (CO) is increasingly being accepted as a cytoprotective and homeostatic
molecule with important signalling capabilities in physiological and pathophysiological …

Heme catabolic pathway in inflammation and immune disorders

B Wu, Y Wu, W Tang - Frontiers in pharmacology, 2019 - frontiersin.org
In recent years, the heme catabolic pathway is considered to play an important regulatory
role in cell protection, apoptosis, inflammation, and other physiological and pathological …

The Triple Crown: NO, CO, and H2S in cancer cell biology

PP Oza, K Kashfi - Pharmacology & Therapeutics, 2023 - Elsevier
Nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S) are three
endogenously produced gases with important functions in the vasculature, immune defense …

Beneficial and detrimental roles of heme oxygenase-1 in the neurovascular system

YK Choi, YM Kim - International Journal of Molecular Sciences, 2022 - mdpi.com
Heme oxygenase (HO) has both beneficial and detrimental effects via its metabolites,
including carbon monoxide (CO), biliverdin or bilirubin, and ferrous iron. HO-1 is an …

Versatile applications of metallopolymers

S Goetz, S Zechel, MD Hager, GR Newkome… - Progress in Polymer …, 2021 - Elsevier
The incorporation of metal complexes into polymers leads to functional materials; whereas,
the properties of polymers–easy processability, light weight or the adjustable molar mass …

Carbon monoxide: an essential signalling molecule

BE Mann - Medicinal organometallic chemistry, 2010 - Springer
Carbon monoxide (CO), like nitric oxide (NO), is an essential signalling molecule in humans.
It is active in the cardiovascular system as a vasodilator. In addition, CO possesses anti …

Styrene-maleic acid copolymer-encapsulated CORM2, a water-soluble carbon monoxide (CO) donor with a constant CO-releasing property, exhibits therapeutic …

H Yin, J Fang, L Liao, H Nakamura, H Maeda - Journal of Controlled …, 2014 - Elsevier
Carbon monoxide (CO), the physiological product of heme oxygenase during catabolic
breakdown of heme, has versatile functions and fulfills major anti-oxidative and anti …

(+)-Nootkatone and (+)-valencene from rhizomes of Cyperus rotundus increase survival rates in septic mice due to heme oxygenase-1 induction

K Tsoyi, HJ Jang, YS Lee, YM Kim, HJ Kim… - Journal of …, 2011 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: The rhizomes of Cyperus rotundus have been
used as traditional folk medicine for the treatment of inflammatory diseases. However, the …

Regulation of Endothelial and Vascular Functions by Carbon Monoxide via Crosstalk With Nitric Oxide

YK Choi, YM Kim - Frontiers in Cardiovascular Medicine, 2021 - frontiersin.org
Carbon monoxide (CO), generated by heme oxygenase (HO), has been considered a
signaling molecule in both the cardiovascular and central nervous systems. The biological …

Targeting the heme oxygenase 1/carbon monoxide pathway to resolve lung hyper-inflammation and restore a regulated immune response in cystic fibrosis

C Di Pietro, HH Öz, TS Murray… - Frontiers in …, 2020 - frontiersin.org
In individuals with cystic fibrosis (CF), lung hyper-inflammation starts early in life and is
perpetuated by mucus obstruction and persistent bacterial infections. The continuous tissue …