Exploring vitamin D metabolism and function in cancer
Vitamin D, traditionally known as an essential nutrient, is a precursor of a potent steroid
hormone that regulates a broad spectrum of physiological processes. In addition to its …
hormone that regulates a broad spectrum of physiological processes. In addition to its …
New aspects of vitamin D metabolism and action—Addressing the skin as source and target
D Bikle, S Christakos - Nature Reviews Endocrinology, 2020 - nature.com
Vitamin D has a key role in stimulating calcium absorption from the gut and promoting
skeletal health, as well as many other important physiological functions. Vitamin D is …
skeletal health, as well as many other important physiological functions. Vitamin D is …
The p53 pathway in glioblastoma
Y Zhang, C Dube, M Gibert Jr, N Cruickshanks, B Wang… - Cancers, 2018 - mdpi.com
The tumor suppressor and transcription factor p53 plays critical roles in tumor prevention by
orchestrating a wide variety of cellular responses, including damaged cell apoptosis …
orchestrating a wide variety of cellular responses, including damaged cell apoptosis …
Unravelling mechanisms of p53-mediated tumour suppression
KT Bieging, SS Mello, LD Attardi - Nature Reviews Cancer, 2014 - nature.com
Abstract p53 is a crucial tumour suppressor that responds to diverse stress signals by
orchestrating specific cellular responses, including transient cell cycle arrest, cellular …
orchestrating specific cellular responses, including transient cell cycle arrest, cellular …
Mutant p53 in cancer: new functions and therapeutic opportunities
PAJ Muller, KH Vousden - Cancer cell, 2014 - cell.com
Many different types of cancer show a high incidence of TP53 mutations, leading to the
expression of mutant p53 proteins. There is growing evidence that these mutant p53s have …
expression of mutant p53 proteins. There is growing evidence that these mutant p53s have …
p53 mutations in cancer
PAJ Muller, KH Vousden - Nature cell biology, 2013 - nature.com
In the past fifteen years, it has become apparent that tumour-associated p53 mutations can
provoke activities that are different to those resulting from simply loss of wild-type tumour …
provoke activities that are different to those resulting from simply loss of wild-type tumour …
Vitamin D and cancer: an historical overview of the epidemiology and mechanisms
This is a narrative review of the evidence supporting vitamin D's anticancer actions. The first
section reviews the findings from ecological studies of cancer with respect to indices of solar …
section reviews the findings from ecological studies of cancer with respect to indices of solar …
Mutant p53 partners in crime
MP Kim, G Lozano - Cell Death & Differentiation, 2018 - nature.com
Mutant p53 proteins impart changes in cellular behavior and function through interactions
with proteins that alter gene expression. The milieu of intracellular proteins available to …
with proteins that alter gene expression. The milieu of intracellular proteins available to …
Mutant p53 in cancer: accumulation, gain-of-function, and therapy
X Yue, Y Zhao, Y Xu, M Zheng, Z Feng, W Hu - Journal of molecular biology, 2017 - Elsevier
Tumor suppressor p53 plays a central role in tumor suppression. p53 is the most frequently
mutated gene in human cancer, and over half of human cancers contain p53 mutations …
mutated gene in human cancer, and over half of human cancers contain p53 mutations …
Gain-of-function mutant p53: all the roads lead to tumorigenesis
Y Stein, V Rotter, R Aloni-Grinstein - International journal of molecular …, 2019 - mdpi.com
The p53 protein is mutated in about 50% of human cancers. Aside from losing the tumor-
suppressive functions of the wild-type form, mutant p53 proteins often acquire inherent …
suppressive functions of the wild-type form, mutant p53 proteins often acquire inherent …