TANK-binding kinase 1 (TBK1) is a member of the IKK family and plays a crucial role in the
activation of non-canonical NF-κB signaling and type I interferon responses. The aberrant …

Abstract Interferon Regulatory Factors (IRFs), a family of transcription factors, profoundly
influence the immune system, impacting both physiological and pathological processes …

Background Liver surgery during the perioperative period often leads to a significant
complication known as hepatic ischemia-reperfusion (I/R) injury. Hepatic I/R injury is linked …

Animal longevity is a function of global vital organ functionality and, consequently, a
complex polygenic trait. Yet, monogenic regulators controlling overall or organ-specific …

Hepatocellular adenomas (HAs) are tumors that can develop under different conditions,
including in patients harboring a germline mutation in HNF1A. However, little is known about …

The selective macroautophagy/autophagy pathway is an important pathway of protein
degradation, regulating signal transduction pathways via selective degradation of certain …

Background Metabolic dysfunction-associated fatty liver disease (MAFLD) is now the most
prevalent chronic liver disease worldwide, with an increasing incidence rate. MAFLD is a …

ABSTRACT HNF1A haploinsufficiency underlies the most common form of human
monogenic diabetes (HNF1A-MODY) and hypomorphic HNF1A variants confer type 2 …

In our research, we performed temporal transcriptomic profiling of host cells infected with
Equid alphaherpesvirus 1 by utilizing direct cDNA sequencing based on nanopore MinION …

Single-cell genomics approaches, including low throughput plate-based and high
throughput dropletbased approaches, have revealed a wealth of knowledge on cellular …