Huntington's disease is a genetic neurodegenerative disorder. White matter alterations have
recently been identified as a relevant pathophysiological feature of Huntington's disease, but …

Magnetic Resonance Imaging (MRI), functional MRI (fMRI) and Diffusion Tensor Imaging
(DTI) have been central to characterisation of abnormalities in brain structure and function in …

Atrophy of cortical and subcortical gray matter is apparent in Huntington's disease (HD)
before symptoms manifest. We hypothesized that the white matter (WM) connecting cortical …

Background Postmortem and in vivo imaging data support the hypothesis that premature
myelin breakdown and subsequent homeostatic remyelination attempts with increased …

Although Huntington's disease is largely considered to be a subcortical disease, there is no
clear consensus on whether all deep grey matter loss is a direct downstream consequence …

Objectives: To investigate the function–structure relationship of white matter within different
stages of Huntington's disease (HD) using diffusion tensor imaging (DTI). Experimental …

Huntington's disease is caused by a known genetic mutation and so potentially can be
diagnosed many years before the onset of symptoms. Neuropathological changes have …

The pathology of Huntington's disease (HD) is characterized by diffuse brain atrophy, with
the most substantial neuronal loss occurring in the caudate and putamen. Recent evidence …

Diffusion weighted imaging (DWI) and the trace of diffusion tensor [Trace (D)], a marker of
water molecule diffusivity, provide information on structural integrity of nervous tissues. To …

The ability to image the whole brain through ever more subtle and specific
methods/contrasts has come to play a key role in understanding the basis of brain …