Repair strategies and bioactive functional materials for intervertebral disc

D Wu, G Li, X Zhou, W Zhang, H Liang… - Advanced Functional …, 2022 - Wiley Online Library
Intervertebral disc (IVD) degeneration is the leading cause of low back pain, which
represents a highly prevalent chronic aging‐associated disorder with a large socio …

[HTML][HTML] The potential role of melatonin in retarding intervertebral disc ageing and degeneration: a systematic review

Z Cheng, Q Xiang, J Wang, Y Zhang - Ageing Research Reviews, 2021 - Elsevier
Intervertebral disc degeneration (IDD) is a common degenerative disease of the
musculoskeletal system that develops with age. It is regarded as the main cause of chronic …

[HTML][HTML] TGF-β1-supplemented decellularized annulus fibrosus matrix hydrogels promote annulus fibrosus repair

Q Wei, D Liu, G Chu, Q Yu, Z Liu, J Li, Q Meng… - Bioactive Materials, 2023 - Elsevier
Annulus fibrosus (AF) repair remains a challenge because of its limited self-healing ability.
Endogenous repair strategies combining scaffolds and growth factors show great promise in …

[HTML][HTML] Emerging tissue engineering strategies for annulus fibrosus therapy

A Zhang, Z Cheng, Y Chen, P Shi, W Gan, Y Zhang - Acta Biomaterialia, 2023 - Elsevier
Low back pain is a major public health concern experienced by 80% of the world's
population during their lifetime, which is closely associated with intervertebral disc (IVD) …

[HTML][HTML] Proper animal experimental designs for preclinical research of biomaterials for intervertebral disc regeneration

Y Peng, X Qing, H Shu, S Tian, W Yang… - Biomaterials …, 2021 - ncbi.nlm.nih.gov
Low back pain is a vital musculoskeletal disease that impairs life quality, leads to disability
and imposes heavy economic burden on the society, while it is greatly attributed to …

Tension-activated nanofiber patches delivering an anti-inflammatory drug improve repair in a goat intervertebral disc herniation model

AP Peredo, SE Gullbrand, CS Friday… - Science Translational …, 2023 - science.org
Conventional microdiscectomy treatment for intervertebral disc herniation alleviates pain but
does not repair the annulus fibrosus, resulting in a high incidence of recurrent herniation …

[HTML][HTML] Intervertebral disc degeneration and regeneration: a motion segment perspective

B Ashinsky, HE Smith, RL Mauck… - European cells & …, 2021 - ncbi.nlm.nih.gov
Back and neck pain have become a primary cause of disability and healthcare spending
globally. While the causes of back pain are multifactorial, intervertebral disc degeneration is …

[HTML][HTML] Regulating pyroptosis by mesenchymal stem cells and extracellular vesicles: A promising strategy to alleviate intervertebral disc degeneration

S Yang, Y Zhang, Q Peng, B Meng, J Wang… - Biomedicine & …, 2024 - Elsevier
Intervertebral disc degeneration (IVDD) is a main cause of low back pain (LBP), which can
lead to disability and thus generate a heavy burden on society. IVDD is characterized by a …

[HTML][HTML] Can extracellular vesicles be considered as a potential frontier in the treatment of intervertebral disc disease?

S Zhu, J Wang, M Suo, H Huang, X Liu, J Wang… - Ageing Research …, 2023 - Elsevier
As a global public health problem, low back pain (LBP) caused by intervertebral disc
degeneration (IDD) seriously affects patients' quality of life. In addition, the prevalence of …

[HTML][HTML] Application of mesenchymal stem cell-derived exosomes from different sources in intervertebral disc degeneration

Y Xia, R Yang, Y Hou, H Wang, Y Li, J Zhu… - … in bioengineering and …, 2022 - frontiersin.org
Intervertebral disc degeneration (IVDD) is a main cause of lower back pain, leading to
psychological and economic burdens to patients. Physical therapy only delays pain in …