The acquisition of genetic alterations, clonal evolution, and the tumor microenvironment
promote cancer progression, metastasis and therapy resistance. These events correspond …

The cancer stem cell (CSC) model defines tumors as hierarchically organized entities,
containing a small population of tumorigenic CSC, or tumour-initiating cells, placed at the …

Down syndrome (DS) is the most frequent chromosomal abnormality that causes intellectual
disability, resulting from the presence of an extra complete or segment of chromosome 21 …

Background Selective toxicity antibacteribiotics is considered to be due to interactions with
targets either being unique to bacteria or being characterized by a dichotomy between pro …

Simple Summary Mitochondria, often called “the powerhouse of the cell”, generate most of
the energy required for all cellular processes. Mitochondria also provide a platform for …

Triple negative breast cancer (TNBC) is one of the most aggressive subtypes of breast
cancer with the worst prognosis after chemo‐or radiation therapy. This is mainly due to the …

Cancer is a common and complex disease with high incidence and mortality rates, which
causes a severe public health problem worldwide. As one of the standard therapeutic …

Triple-negative breast cancer (TNBC) is ineligible for hormonal therapy and Her-2-targeted
therapy due to the negative expression of the estrogen receptor, progesterone receptor, and …

Aims: A subpopulation of cancer cells, termed cancer stem cells (CSCs), has stemness
properties, such as self-renewal and differentiation, which drive cancer recurrence and …

Traditional cancer treatments based on chemo-and/or radiotherapy effectively kill only
differentiated cancer cells, while metastasis and recurrences are caused by surviving cancer …