Ruptured and intact plasma membranes are classically considered as hallmarks of necrotic
and apoptotic cell death, respectively. As such, apoptosis is usually considered a non …

The pivotal role of lysosomes in cellular processes is increasingly appreciated. An
understanding of the balanced interplay between the activity of acidic hydrolases, lysosomal …

During respiration, humans breathe in more than 10,000 liters of non-sterile air daily,
allowing some pathogens access to alveoli. Interestingly, alveoli outnumber alveolar …

Apoptosis is a genetically regulated cell suicide programme mediated by activation of the
effector caspases 3, 6 and 7. If apoptotic cells are not scavenged, they progress to a lytic and …

Necrosis of infected macrophages constitutes a critical pathogenetic event in tuberculosis by
releasing mycobacteria into the growth-permissive extracellular environment. In zebrafish …

Granulomas are organized aggregates of macrophages, often with characteristic
morphological changes, and other immune cells. These evolutionarily ancient structures …

The study of host–pathogen interactions has illuminated fundamental research avenues in
both infection and cell biology. Zebrafish (Danio rerio) larvae are genetically tractable …

Drug repurposing is potentially the fastest available option in the race to identify safe and
efficacious drugs that can be used to prevent and/or treat COVID‐19. By describing the life …

Mycobacterium tuberculosis (Mtb) enters the host in aerosol droplets deposited in lung
alveoli, where the bacteria first encounter lung-resident alveolar macrophages. We studied …

Dendritic cells (DCs) patrol their environment by linking antigen acquisition by
macropinocytosis to cell locomotion. DC activation upon bacterial sensing inhibits …