The physiological functions of human peroxisomes

RJA Wanders, M Baes, D Ribeiro… - Physiological …, 2023 - journals.physiology.org
Peroxisomes are subcellular organelles that play a central role in human physiology by
catalyzing a range of unique metabolic functions. The importance of peroxisomes for human …

Redox crosstalk at endoplasmic reticulum (ER) membrane contact sites (MCS) uses toxic waste to deliver messages

ED Yoboue, R Sitia, T Simmen - Cell death & disease, 2018 - nature.com
Many cellular redox reactions housed within mitochondria, peroxisomes and the
endoplasmic reticulum (ER) generate hydrogen peroxide (H2O2) and other reactive oxygen …

Reprogramming methanol utilization pathways to convert Saccharomyces cerevisiae to a synthetic methylotroph

C Zhan, X Li, G Lan, EEK Baidoo, Y Yang, Y Liu… - Nature Catalysis, 2023 - nature.com
Methanol, an organic one-carbon (C1) compound, represents an attractive alternative
carbon source for microbial fermentation. Despite considerable advancements in methanol …

Peroxisomal metabolite and cofactor transport in humans

S Chornyi, L IJlst, CWT van Roermund… - Frontiers in cell and …, 2021 - frontiersin.org
Peroxisomes are membrane-bound organelles involved in many metabolic pathways and
essential for human health. They harbor a large number of enzymes involved in the different …

[HTML][HTML] Human peroxisomal NAD+/NADH homeostasis is regulated by two independent NAD (H) shuttle systems

S Chornyi, CF Costa, L IJlst, M Fransen… - Free Radical Biology …, 2023 - Elsevier
Reduced (NADH) and oxidized (NAD+) nicotinamide adenine dinucleotides are ubiquitous
hydride-donating/accepting cofactors that are essential for cellular bioenergetics …

Peroxisomal NAD(H) Homeostasis in the Yeast Debaryomyces hansenii Depends on Two Redox Shuttles and the NAD+ Carrier, Pmp47

S Turkolmez, S Chornyi, S Alhajouj, L IJlst… - Biomolecules, 2023 - mdpi.com
Debaryomyces hansenii is considered an unconventional yeast with a strong
biotechnological potential, which can produce and store high amounts of lipids. However …

Fatty acid oxidation in peroxisomes: enzymology, metabolic crosstalk with other organelles and peroxisomal disorders

RJA Wanders, FM Vaz, HR Waterham… - Peroxisome biology …, 2020 - Springer
Peroxisomes play a central role in metabolism as exemplified by the fact that many genetic
disorders in humans have been identified through the years in which there is an impairment …

Anaerobic peroxisomes in Entamoeba histolytica metabolize myo-inositol

Z Verner, V Žárský, T Le, RK Narayanasamy… - PLoS …, 2021 - journals.plos.org
Entamoeba histolytica is believed to be devoid of peroxisomes, like most anaerobic protists.
In this work, we provided the first evidence that peroxisomes are present in E. histolytica …

Peroxisomal targeting of a protein phosphatase type 2C via mitochondrial transit

T Stehlik, M Kremp, J Kahnt, M Bölker… - Nature communications, 2020 - nature.com
Correct intracellular distribution of proteins is critical for the function of eukaryotic cells.
Certain proteins are targeted to more than one cellular compartment, eg to mitochondria and …

Pls1 is a peroxisomal matrix protein with a role in regulating lysine biosynthesis

Y David, IG Castro, E Yifrach, C Bibi, E Katawi… - Cells, 2022 - mdpi.com
Peroxisomes host essential metabolic enzymes and are crucial for human health and
survival. Although peroxisomes were first described over 60 years ago, their entire proteome …