The kynurenine pathway (KP) is the major route for tryptophan (TRP) metabolism in most
mammalian tissues. The KP metabolizes TRP into a number of neuroactive metabolites …

Impaired kidney function and increased inflammatory process occurring in the course of
Chronic Kidney Disease (CKD) contribute to the development of complex amino-acid …

The kynurenine pathway (KP) is the main route of tryptophan degradation whose final
product is NAD+. The metabolism of tryptophan can be altered in ageing and with …

The kynurenine pathway (KP) of tryptophan degradation contains several neuroactive
metabolites that may influence brain function in health and disease. Mounting focus has …

The main product of L-tryptophan (TRP) kynurenine pathway degradation in peripheral
tissues is L-kynurenine (KYN), which is further converted to a series of metabolites, such as …

The hepatic-renal toxicity associated with cyclophosphamide (CYP) treatment in both
animals and humans have been reported. Quercetin, a dietary flavonoid, is known to elicit …

The role of serotonin (5-HT) in psychopathology has been investigated for decades. Among
others, symptoms of depression, panic, aggression and suicidality have been associated …

In uremia a great number of the endogenous metabolites that are ordinarily excreted in urine
accumulate in the blood. Among these are the products of KYN degradation. In the present …

This study evaluated the role of quercetin against cyclophosphamide‐induced distortion of
rat testicular function. Adult rats were administered cyclophosphamide (100 mg/kg) …

Background: Kidneys are involved in tryptophan (TRP) metabolism in two ways. They
eliminate TRP derivatives on the one hand, and they produce several enzymes taking part in …