NF-κB-mediated neuroinflammation in Parkinson's disease and potential therapeutic effect of polyphenols
SS Singh, SN Rai, H Birla, W Zahra, AS Rathore… - Neurotoxicity …, 2020 - Springer
Different animal and human studies from last two decades in the case of Parkinson's
disease (PD) have concentrated on oxidative stress due to increased inflammation and …
disease (PD) have concentrated on oxidative stress due to increased inflammation and …
Oxidative stress and neuroinflammation potentiate each other to promote progression of dopamine neurodegeneration
J He, G Zhu, G Wang, F Zhang - Oxidative medicine and …, 2020 - Wiley Online Library
Parkinson's disease (PD) is a chronic and complex disease of the central nervous system
(CNS). Progressive loss of dopamine (DA) neurons in midbrain substantia nigra is …
(CNS). Progressive loss of dopamine (DA) neurons in midbrain substantia nigra is …
Aggregated α‐synuclein activates microglia: a process leading to disease progression in Parkinson's disease
W Zhang, T Wang, Z Pei, DS Miller, X Wu… - The FASEB …, 2005 - Wiley Online Library
ABSTRACT A growing body of evidence indicates that an inflammatory process in the
substantia nigra, characterized by activation of resident microglia, likely either initiates or …
substantia nigra, characterized by activation of resident microglia, likely either initiates or …
Behavioral characterization of a unilateral 6-OHDA-lesion model of Parkinson's disease in mice
Parkinson's disease (PD) is one of the most common neurodegenerative disorders. Several
toxin-induced animals models simulate the motor deficits occurring in PD. Among them, the …
toxin-induced animals models simulate the motor deficits occurring in PD. Among them, the …
A model of L-DOPA-induced dyskinesia in 6-hydroxydopamine lesioned mice: relation to motor and cellular parameters of nigrostriatal function
l-DOPA-induced dyskinesia is a major complication of l-DOPA pharmacotherapy in
Parkinson's disease, and is thought to depend on abnormal cell signaling in the basal …
Parkinson's disease, and is thought to depend on abnormal cell signaling in the basal …
Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine hydrochloride …
A Fujita, H Yamaguchi, R Yamasaki, Y Cui… - Journal of …, 2018 - Springer
Background The first pathology observed in Parkinson's disease (PD) is 'dying back'of
striatal dopaminergic (DA) terminals. Connexin (Cx) 30, an astrocytic gap junction protein, is …
striatal dopaminergic (DA) terminals. Connexin (Cx) 30, an astrocytic gap junction protein, is …
[HTML][HTML] A partial lesion model of Parkinson's disease in mice–characterization of a 6-OHDA-induced medial forebrain bundle lesion
The most frequently used animal models for Parkinson's disease (PD) utilize unilateral
injection of 6-hydroxydopamine (6-OHDA) in the medial forebrain bundle (MFB), which …
injection of 6-hydroxydopamine (6-OHDA) in the medial forebrain bundle (MFB), which …
Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease
Several lines of evidence point to a significant role of neuroinflammation in Parkinson's
disease (PD) and other neurodegenerative disorders. In the present study we examined the …
disease (PD) and other neurodegenerative disorders. In the present study we examined the …
Trophic factor gene therapy for Parkinson's disease
JH Kordower, A Bjorklund - Movement Disorders, 2013 - Wiley Online Library
Parkinson's disease (PD) is a chronic and progressive neurodegenerative movement
disorder for which there is presently no cure. Pharmacological remedies targeting the …
disorder for which there is presently no cure. Pharmacological remedies targeting the …
Time course of dopamine neuron loss and glial response in the 6‐OHDA striatal mouse model of P arkinson's disease
Abstract The 6‐hydroxydopamine (6‐OHDA) neurotoxic lesion of the midbrain dopamine
(DA) system is one of the most widely used techniques for modelling Parkinson's disease in …
(DA) system is one of the most widely used techniques for modelling Parkinson's disease in …