[HTML][HTML] NADPH oxidases (NOX): an overview from discovery, molecular mechanisms to physiology and pathology
The reactive oxygen species (ROS)-producing enzyme NADPH oxidase (NOX) was first
identified in the membrane of phagocytic cells. For many years, its only known role was in …
identified in the membrane of phagocytic cells. For many years, its only known role was in …
[HTML][HTML] Oxidative stress in cancer cell metabolism
Reactive oxygen species (ROS) are important in regulating normal cellular processes
whereas deregulated ROS leads to the development of a diseased state in humans …
whereas deregulated ROS leads to the development of a diseased state in humans …
[HTML][HTML] The double-edged roles of ROS in cancer prevention and therapy
Y Wang, H Qi, Y Liu, C Duan, X Liu, T Xia, D Chen… - Theranostics, 2021 - ncbi.nlm.nih.gov
Reactive oxygen species (ROS) serve as cell signaling molecules generated in oxidative
metabolism and are associated with a number of human diseases. The reprogramming of …
metabolism and are associated with a number of human diseases. The reprogramming of …
[HTML][HTML] ROS in cancer therapy: the bright side of the moon
Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have
evolved as regulators of important signaling pathways. It is now well accepted that moderate …
evolved as regulators of important signaling pathways. It is now well accepted that moderate …
The multifaceted role of reactive oxygen species in tumorigenesis
Redox homeostasis is an essential requirement of the biological systems for performing
various normal cellular functions including cellular growth, differentiation, senescence …
various normal cellular functions including cellular growth, differentiation, senescence …
[HTML][HTML] Reactive oxygen species in the tumor microenvironment: an overview
Reactive oxygen species (ROS) are important signaling molecules in cancer. The level of
ROS will determine physiological effects. While high levels of ROS can cause damage to …
ROS will determine physiological effects. While high levels of ROS can cause damage to …
ROS signalling in the biology of cancer
JN Moloney, TG Cotter - Seminars in cell & developmental biology, 2018 - Elsevier
Increased reactive oxygen species (ROS) production has been detected in various cancers
and has been shown to have several roles, for example, they can activate pro-tumourigenic …
and has been shown to have several roles, for example, they can activate pro-tumourigenic …
[HTML][HTML] Tumor-selective catalytic nanomedicine by nanocatalyst delivery
Tumor cells metabolize in distinct pathways compared with most normal tissue cells. The
resulting tumor microenvironment would provide characteristic physiochemical conditions …
resulting tumor microenvironment would provide characteristic physiochemical conditions …
NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer
Multiple cancers regulate oxidative stress by activating the transcription factor NRF2 through
mutation of its negative regulator, KEAP1. NRF2 has been studied extensively in KEAP1 …
mutation of its negative regulator, KEAP1. NRF2 has been studied extensively in KEAP1 …
[HTML][HTML] Targeting metabolism for cancer therapy
A Luengo, DY Gui, MG Vander Heiden - Cell chemical biology, 2017 - cell.com
Metabolic reprogramming contributes to tumor development and introduces metabolic
liabilities that can be exploited to treat cancer. Chemotherapies targeting metabolism have …
liabilities that can be exploited to treat cancer. Chemotherapies targeting metabolism have …