Polygenic adaptation: a unifying framework to understand positive selection
Most adaption processes have a polygenic genetic basis, but even with the recent explosive
growth of genomic data we are still lacking a unified framework describing the dynamics of …
growth of genomic data we are still lacking a unified framework describing the dynamics of …
Detecting natural selection in genomic data
JJ Vitti, SR Grossman, PC Sabeti - Annual review of genetics, 2013 - annualreviews.org
The past fifty years have seen the development and application of numerous statistical
methods to identify genomic regions that appear to be shaped by natural selection. These …
methods to identify genomic regions that appear to be shaped by natural selection. These …
Genetics of adaptation
K Bomblies, CL Peichel - Proceedings of the National …, 2022 - National Acad Sciences
The rediscovery of Mendel's work showing that the heredity of phenotypes is controlled by
discrete genes was followed by the reconciliation of Mendelian genetics with evolution by …
discrete genes was followed by the reconciliation of Mendelian genetics with evolution by …
Population genomics of rapid adaptation by soft selective sweeps
Organisms can often adapt surprisingly quickly to evolutionary challenges, such as the
application of pesticides or antibiotics, suggesting an abundant supply of adaptive genetic …
application of pesticides or antibiotics, suggesting an abundant supply of adaptive genetic …
Revisiting an old riddle: what determines genetic diversity levels within species?
Understanding why some species have more genetic diversity than others is central to the
study of ecology and evolution, and carries potentially important implications for …
study of ecology and evolution, and carries potentially important implications for …
The QTN program and the alleles that matter for evolution: all that's gold does not glitter
MV Rockman - Evolution, 2012 - academic.oup.com
The search for the alleles that matter, the quantitative trait nucleotides (QTNs) that underlie
heritable variation within populations and divergence among them, is a popular pursuit. But …
heritable variation within populations and divergence among them, is a popular pursuit. But …
The genetics of human adaptation: hard sweeps, soft sweeps, and polygenic adaptation
There has long been interest in understanding the genetic basis of human adaptation. To
what extent are phenotypic differences among human populations driven by natural …
what extent are phenotypic differences among human populations driven by natural …
Adaptation from standing genetic variation
RDH Barrett, D Schluter - Trends in ecology & evolution, 2008 - cell.com
Populations adapt to novel environments in two distinct ways: selection on pre-existing
genetic variation and selection on new mutations. These alternative sources of beneficial …
genetic variation and selection on new mutations. These alternative sources of beneficial …
The Many Landscapes of Recombination in Drosophila melanogaster
JM Comeron, R Ratnappan, S Bailin - 2012 - journals.plos.org
Recombination is a fundamental biological process with profound evolutionary implications.
Theory predicts that recombination increases the effectiveness of selection in natural …
Theory predicts that recombination increases the effectiveness of selection in natural …
[HTML][HTML] The molecular genetics of crop domestication
JF Doebley, BS Gaut, BD Smith - Cell, 2006 - cell.com
Ten thousand years ago human societies around the globe began to transition from hunting
and gathering to agriculture. By 4000 years ago, ancient peoples had completed the …
and gathering to agriculture. By 4000 years ago, ancient peoples had completed the …