Polygenic adaptation: a unifying framework to understand positive selection

N Barghi, J Hermisson, C Schlötterer - Nature Reviews Genetics, 2020 - nature.com
Most adaption processes have a polygenic genetic basis, but even with the recent explosive
growth of genomic data we are still lacking a unified framework describing the dynamics of …

Detecting natural selection in genomic data

JJ Vitti, SR Grossman, PC Sabeti - Annual review of genetics, 2013 - annualreviews.org
The past fifty years have seen the development and application of numerous statistical
methods to identify genomic regions that appear to be shaped by natural selection. These …

Genetics of adaptation

K Bomblies, CL Peichel - Proceedings of the National …, 2022 - National Acad Sciences
The rediscovery of Mendel's work showing that the heredity of phenotypes is controlled by
discrete genes was followed by the reconciliation of Mendelian genetics with evolution by …

Population genomics of rapid adaptation by soft selective sweeps

PW Messer, DA Petrov - Trends in ecology & evolution, 2013 - cell.com
Organisms can often adapt surprisingly quickly to evolutionary challenges, such as the
application of pesticides or antibiotics, suggesting an abundant supply of adaptive genetic …

Revisiting an old riddle: what determines genetic diversity levels within species?

EM Leffler, K Bullaughey, DR Matute, WK Meyer… - 2012 - journals.plos.org
Understanding why some species have more genetic diversity than others is central to the
study of ecology and evolution, and carries potentially important implications for …

The QTN program and the alleles that matter for evolution: all that's gold does not glitter

MV Rockman - Evolution, 2012 - academic.oup.com
The search for the alleles that matter, the quantitative trait nucleotides (QTNs) that underlie
heritable variation within populations and divergence among them, is a popular pursuit. But …

The genetics of human adaptation: hard sweeps, soft sweeps, and polygenic adaptation

JK Pritchard, JK Pickrell, G Coop - Current biology, 2010 - cell.com
There has long been interest in understanding the genetic basis of human adaptation. To
what extent are phenotypic differences among human populations driven by natural …

Adaptation from standing genetic variation

RDH Barrett, D Schluter - Trends in ecology & evolution, 2008 - cell.com
Populations adapt to novel environments in two distinct ways: selection on pre-existing
genetic variation and selection on new mutations. These alternative sources of beneficial …

The Many Landscapes of Recombination in Drosophila melanogaster

JM Comeron, R Ratnappan, S Bailin - 2012 - journals.plos.org
Recombination is a fundamental biological process with profound evolutionary implications.
Theory predicts that recombination increases the effectiveness of selection in natural …

[HTML][HTML] The molecular genetics of crop domestication

JF Doebley, BS Gaut, BD Smith - Cell, 2006 - cell.com
Ten thousand years ago human societies around the globe began to transition from hunting
and gathering to agriculture. By 4000 years ago, ancient peoples had completed the …