Chemistry of MRI contrast agents: current challenges and new frontiers

J Wahsner, EM Gale, A Rodríguez-Rodríguez… - Chemical …, 2018 - ACS Publications
Tens of millions of contrast-enhanced magnetic resonance imaging (MRI) exams are
performed annually around the world. The contrast agents, which improve diagnostic …

The use of the macrocyclic chelator DOTA in radiochemical separations

Z Baranyai, G Tircsó, F Rösch - European Journal of Inorganic …, 2020 - Wiley Online Library
Radiometals play an important role in the diagnosis of physiological processes in vivo by
means of imaging technologies, but also increasingly contribute to the treatment of diseases …

Metal-involved theranostics: An emerging strategy for fighting Alzheimer's disease

X Wang, X Wang, Z Guo - Coordination Chemistry Reviews, 2018 - Elsevier
Alzheimer's disease (AD) is the most prevalent illness among the neurodegenerative
disorders that are progressive, irreversible and incurable so far. Although the etiological …

Amyloid β-targeted metal complexes for potential applications in Alzheimer's disease

H Liu, Y Qu, X Wang - Future medicinal chemistry, 2018 - Taylor & Francis
Alzheimer's disease (AD) is currently an incurable neurodegenerative disorder that affects
millions of people around the world. The aggregation of amyloid-β peptides (Aβ), one of the …

Magnetic nanoparticles applications for amyloidosis study and detection: a review

J Pansieri, M Gerstenmayer, F Lux, S Mériaux… - Nanomaterials, 2018 - mdpi.com
Magnetic nanoparticles (MNPs) have great potential in biomedical and clinical applications
because of their many unique properties. This contribution provides an overview of the …

Development of a 213Bi-Labeled Pyridyl Benzofuran for Targeted α-Therapy of Amyloid-β Aggregates

AA Bender, EK Kirkeby, DJ Cross… - Journal of Nuclear …, 2024 - jnm.snmjournals.org
Alzheimer disease is a neurodegenerative disorder with limited treatment options. It is
characterized by the presence of several biomarkers, including amyloid-β aggregates, which …

Lanthanide complexes in molecular magnetic resonance imaging and theranostics

S Lacerda, É Tóth - ChemMedChem, 2017 - Wiley Online Library
Lanthanide complexes have attracted much attention in the biomedical field, and today
various imaging applications make use of their versatile magnetic and luminescence …

Efficient characterization of multiple binding sites of small molecule imaging ligands on amyloid-beta, tau and alpha-synuclein

J Sobek, J Li, BF Combes, JA Gerez… - European journal of …, 2024 - Springer
Purpose There is an unmet need for compounds to detect fibrillar forms of alpha-synuclein
(αSyn) and 4-repeat tau, which are critical in many neurodegenerative diseases. Here, we …

Alzheimer's disease: The use of contrast agents for magnetic resonance imaging to detect amyloid beta peptide inside the brain

M Salerno, DSD Porqueras - Coordination Chemistry Reviews, 2016 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disease that causes progressive and
irreversible loss of mental functions. There is no cure for the disease, which worsens as it …

Lanthanide conjugates as versatile instruments for therapy and diagnostics

C Herlan, S Bräse - Dalton Transactions, 2020 - pubs.rsc.org
Lanthanides have demonstrated outstanding properties in many fields of research including
biology and medicinal chemistry. Their unique luminescence and magnetic properties make …