Molybdenum enzymes and how they support virulence in pathogenic bacteria
Mononuclear molybdoenzymes are highly versatile catalysts that occur in organisms in all
domains of life, where they mediate essential cellular functions such as energy generation …
domains of life, where they mediate essential cellular functions such as energy generation …
[HTML][HTML] Molybdenum cofactor biology, evolution and deficiency
The molybdenum cofactor (Moco) represents an ancient metal‑sulfur cofactor, which
participates as catalyst in carbon, nitrogen and sulfur cycles, both on individual and global …
participates as catalyst in carbon, nitrogen and sulfur cycles, both on individual and global …
Molybdenum cofactor deficiency in humans
L Johannes, CY Fu, G Schwarz - Molecules, 2022 - mdpi.com
Molybdenum cofactor (Moco) deficiency (MoCD) is characterized by neonatal-onset
myoclonic epileptic encephalopathy and dystonia with cerebral MRI changes similar to …
myoclonic epileptic encephalopathy and dystonia with cerebral MRI changes similar to …
Selective transformations of carbohydrates inspired by radical-based enzymatic mechanisms
CE Suh, HM Carder, AE Wendlandt - ACS Chemical Biology, 2021 - ACS Publications
Enzymes are a longstanding source of inspiration for synthetic reaction development.
However, enzymatic reactivity and selectivity are frequently untenable in a synthetic context …
However, enzymatic reactivity and selectivity are frequently untenable in a synthetic context …
Tracing of Acyl Carrier Protein-channeled Mitomycin Intermediates in Streptomyces caespitosus Facilitates Characterization of the Biosynthetic Steps for AHBA–GlcN …
S Wang, Y Cheng, X Wang, Q Yang… - Journal of the American …, 2022 - ACS Publications
Mitomycins are a family of naturally occurring, potent alkylating agents in which the C
member has been clinically used for cancer chemotherapy for over 5 decades. In …
member has been clinically used for cancer chemotherapy for over 5 decades. In …
HygY is a twitch radical SAM epimerase with latent dehydrogenase activity revealed upon mutation of a single cysteine residue
RA Besandre, Z Chen, I Davis, J Zhang… - Journal of the …, 2021 - ACS Publications
HygY is a SPASM/twitch radical SAM enzyme hypothesized to catalyze the C2′-
epimerization of galacamine during the biosynthesis of hygromycin B. This activity is …
epimerization of galacamine during the biosynthesis of hygromycin B. This activity is …
Spin‐Regulated Electron Transfer and Exchange‐Enhanced Reactivity in Fe4S4‐Mediated Redox Reaction of the Dph2 Enzyme During the Biosynthesis of …
Abstract The [4Fe‐4S]‐dependent radical S‐adenosylmethionine (SAM) proteins is one of
large families of redox enzymes that are able to carry a panoply of challenging …
large families of redox enzymes that are able to carry a panoply of challenging …
Characterizing SPASM/twitch domain-containing radical SAM enzymes by EPR spectroscopy
Owing to their importance, diversity and abundance of generated paramagnetic species,
radical S-adenosylmethionine (rSAM) enzymes have become popular targets for electron …
radical S-adenosylmethionine (rSAM) enzymes have become popular targets for electron …
Mechanism of reduction of an aminyl radical intermediate in the radical SAM GTP 3′, 8-cyclase MoaA
The diversity of the reactions catalyzed by radical S-adenosyl-l-methionine (SAM) enzymes
is achieved at least in part through the variety of mechanisms to quench their radical …
is achieved at least in part through the variety of mechanisms to quench their radical …
Harnessing Escherichia coli for Bio-Based Production of Formate under Pressurized H2 and CO2 Gases
Escherichia coli is a Gram-negative bacterium that is a workhorse for biotechnology. The
organism naturally performs a mixed-acid fermentation under anaerobic conditions where it …
organism naturally performs a mixed-acid fermentation under anaerobic conditions where it …