Epithelial surfaces line the body and provide a crucial interface between the body and the
external environment. Tissue-resident epithelial γδ T cells represent a major T cell …

Butyrophilin molecules (commonly contracted to BTN), collectively take their name from the
eponymous protein in cow's milk. They are considered to be members of the B7 family of …

Human regulatory macrophages (Mreg) have shown early clinical promise as a cell-based
adjunct immunosuppressive therapy in solid organ transplantation. It is hypothesised that …

The B7 family of co-stimulatory molecules has an important role in driving the activation and
inhibition of immune cells. Evolving data have shown that a related family of molecules—the …

Phage immunoprecipitation sequencing (PhIP-seq) allows for unbiased, proteome-wide
autoantibody discovery across a variety of disease settings, with identification of disease …

To maximize the potential of genomics in medicine, it is essential to establish databases of
genomic variants for ethno‐geographic groups that can be used for filtering and prioritizing …

Background A first-in-human, randomized pilot phase II clinical trial combining vaccines
targeting overexpressed, non-mutated tumor blood vessel antigens (TBVA) and tyrosine …

Abstract Several Butyrophilin (BTN) and Btn‐like (BTNL) molecules control T lymphocyte
responses, and are genetically associated with inflammatory disorders and cancer. In this …

Pediatric glioblastoma (pGBM) is a lethal cancer with no effective therapies. To understand
the mechanisms of tumor evolution in this cancer, we performed whole-genome sequencing …

Abstract Treatment response to antidepressants is limited and varies among patients with
major depressive disorder (MDD). To discover genes and mechanisms related to the …