The comet assay is a versatile method to detect nuclear DNA damage in individual
eukaryotic cells, from yeast to human. The types of damage detected encompass DNA …

The comet assay is a widely used test for the detection of DNA damage and repair activity.
However, there are interlaboratory differences in reported levels of baseline and induced …

Metal‐based nanoparticles (NPs) are particularly important tools in tissue engineering‐,
drug carrier‐, interventional therapy‐, and biobased technologies. However, their complex …

The comet assay or single cell gel electrophoresis, is the most common method used to
measure strand breaks and a variety of other DNA lesions in human populations. To …

Oxidatively generated damage to DNA has been implicated in the pathogenesis of a wide
variety of diseases. Increasingly, interest is also focusing upon the effects of damage to the …

Highlights•Twelve different enzyme have been used in combination with the comet
assay.•The enzyme-modified comet assay detects several DNA lesions.•Fpg, followed by …

Abstract Error-corrected Next Generation Sequencing (ecNGS) is rapidly emerging as a
valuable, highly sensitive and accurate method for detecting and characterizing mutations in …

The alkaline comet assay, or single cell gel electrophoresis, is one of the most popular
methods for assessing DNA damage in human population. One of the open issues …

Genotoxic pollutants lead to both DNA damage and changes in cell repair mechanisms.
Selecting suitable biomonitors is a fundamental step in genotoxicity studies. Thus, zebrafish …

The comet assay is used to measure DNA damage induced by chemical and physical
agents. High concentrations of test agents may cause cytotoxicity or cell death, which may …