[HTML][HTML] Targeting glycosylation: a new road for cancer drug discovery
Cancer is a deadly disease that encompasses numerous cellular modifications. Among
them, alterations in glycosylation are a proven reliable hallmark of cancer, with most …
them, alterations in glycosylation are a proven reliable hallmark of cancer, with most …
[HTML][HTML] The hidden potential of glycomarkers: Glycosylation studies in the service of cancer diagnosis and treatment
Abstract Changes in the glycosylation process appear early in carcinogenesis and evolve
with the growth and spread of cancer. The correlation of the characteristic glycosylation …
with the growth and spread of cancer. The correlation of the characteristic glycosylation …
Gold nanoparticles modified reduced graphene oxide nanosheets based dual-quencher for highly sensitive detection of carcinoembryonic antigen
In the current scenario, the dominance of cancer is becoming a disastrous threat to mankind.
Therefore, an advanced analytical approach is desired as the need of the hour for early …
Therefore, an advanced analytical approach is desired as the need of the hour for early …
Gas-mediated immunoassay for the carcinoembryonic antigen at atmospheric pressure with smartphone coupling with the fluorescence quenching length of …
S Liu, D Lin, Y Lai, L Hou, T Lin, S Zhao - Analytical Chemistry, 2022 - ACS Publications
By combining the photothermal properties of the 3, 3′, 5, 5′-tetramethylbenzidine
oxidation product (TMBox) with the sensitive quenching of perovskite fluorescence by …
oxidation product (TMBox) with the sensitive quenching of perovskite fluorescence by …
[HTML][HTML] ST6Gal1 targets the ectodomain of ErbB2 in a site-specific manner and regulates gastric cancer cell sensitivity to trastuzumab
The clinical performance of the therapeutic monoclonal antibody trastuzumab in the
treatment of ErbB2-positive unresectable gastric cancer (GC) is severely hampered by the …
treatment of ErbB2-positive unresectable gastric cancer (GC) is severely hampered by the …
[HTML][HTML] Glycans as targets for drug delivery in cancer
Simple Summary Alterations in glycosylation are frequently observed in cancer cells.
Different strategies have been proposed to increase drug delivery to the tumor site in order …
Different strategies have been proposed to increase drug delivery to the tumor site in order …
Fabrication of Poly-l-lysine-Functionalized Graphene Quantum Dots for the Label-Free Fluorescent-Based Detection of Carcinoembryonic Antigen
The diagnosis of tumor biomarkers is an attentive approach for the early detection and
treatment of cancer. However, a cost-effective, simple, rapid, selective, and sensitive method …
treatment of cancer. However, a cost-effective, simple, rapid, selective, and sensitive method …
[HTML][HTML] Specific (sialyl-) Lewis core 2 O-glycans differentiate colorectal cancer from healthy colon epithelium
Cells are covered with a dense layer of carbohydrates, some of which are solely present on
neoplastic cells. The so-called tumor-associated carbohydrate antigens (TACAs) are …
neoplastic cells. The so-called tumor-associated carbohydrate antigens (TACAs) are …
[HTML][HTML] Esophageal, gastric and colorectal cancers: Looking beyond classical serological biomarkers towards glycoproteomics-assisted precision oncology
E Fernandes, J Sores, S Cotton, A Peixoto… - Theranostics, 2020 - ncbi.nlm.nih.gov
Abstract Esophageal (OC), gastric (GC) and colorectal (CRC) cancers are amongst the
digestive track tumors with higher incidence and mortality due to significant molecular …
digestive track tumors with higher incidence and mortality due to significant molecular …
[HTML][HTML] The extracellular small leucine-rich proteoglycan biglycan is a key player in gastric cancer aggressiveness
F Pinto, L Santos-Ferreira, MT Pinto, C Gomes… - Cancers, 2021 - mdpi.com
Simple Summary Approximately 80% of gastric cancer patients are diagnosed at advanced
stages with an average five-year survival rate of less than 30%. Alterations of the …
stages with an average five-year survival rate of less than 30%. Alterations of the …