Mitochondrial dysfunction has been associated with neurodegeneration in Parkinson's
disease (PD) for over 30 years. Despite this, the role of mitochondrial dysfunction as an …

With the hope that disease-modifying treatments could target the molecular basis of
Parkinson's disease, even before the onset of symptoms, we propose a biologically based …

It has been 15 years since the birth of human induced pluripotent stem cell (iPSC)
technology in 2007, and the scope of its application has been expanding. In addition to the …

Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic
Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial …

Genes | Free Full-Text | Monogenic Parkinson’s Disease: Genotype, Phenotype,
Pathophysiology, and Genetic Testing Next Article in Journal enChIP-Seq Analyzer: A …

Parkinson's Disease (PD) is a highly prevalent neurodegenerative disease among older
adults. PD neuropathology is marked by the progressive loss of the dopaminergic neurons …

Parkinson's disease (PD) is one of the most common neurodegenerative movement
disorders worldwide. There are currently no cures or preventative treatments for PD …

Parkinson's disease (PD) is an age-related neurodegenerative disorder affecting millions of
people worldwide. The disease is characterized by the progressive loss of dopaminergic …

Recently, the genetic variability in lysosomal storage disorders has been implicated in the
pathogenesis of Parkinson's disease. Here, we found that variants in prosaposin (PSAP), a …

Parkinson disease (PD) is a complex neurodegenerative disorder, usually with multifactorial
etiology. It is characterized by prominent movement disorders and non-motor symptoms …