Abstract The Belmont Report's distinction between research and the practice of accepted
therapy has led various authors to suggest that these purportedly distinct activities should be …

Rationale, aims and objectives McHugh and Walker introduced a model of knowledge to
demonstrate that EBM is a form of scientism that ignores important sources of knowledge …

In this essay, we defend the design of the Salk polio vaccine trial and try to put some limits
on the role schemata should play in designing clinical research studies. Our presentation is …

In the clinical research context, comparative effectiveness research (CER) refers to the
comparison of several health-care interventions administered under real-world conditions to …

There is a growing need for broader information on Real-World Effectiveness and safety of
any new intervention, service or protocol vs data limited by standardized and strictly …

Real-world evidence (RWE) research is an increasingly important component of
biopharmaceutical product development and commercialization. The growing industry need …

Real world evidence (RWE) studies serve many purposes and are creating new
opportunities for evidence generation in drug development. The demand for RWE is growing …

We thank Drs Kim and Grzybowski for their interest in our paper1 and for highlighting their
concern about the lack of strict diagnostic criteria for macular edema and the lack of …

In the clinical research context, comparative effectiveness research (CER) refers to the
comparison of several health-care interventions administered under real-world conditions to …