The brain-derived neurotrophic factor (BDNF) is a secretory growth factor that promotes
neuronal proliferation and survival, synaptic plasticity and long-term potentiation in the …

Major depressive disorder (MDD) is a mood disorder that affects behavior and impairs
cognition. A gene potentially important to this disorder is the brain derived neurotrophic …

Analysis of human pathology led Braak to postulate that α-synuclein (α-syn) pathology could
spread from the gut to brain via the vagus nerve. Here, we test this postulate by assessing α …

During fasting and vigorous exercise, a shift of brain cell energy substrate utilization from
glucose to the ketone 3‐hydroxybutyrate (3 OHB) occurs. Studies have shown that 3 OHB …

Women are twice as likely as men to develop major depressive disorder (MDD) and are
more prone to recurring episodes. Hence, we tested the hypothesis that the illness may …

Objective The subgenual anterior cingulate cortex is implicated in the pathology and
treatment response of major depressive disorder. Low levels of brain-derived neurotrophic …

Tau interacts with α-Synuclein (α-Syn) and co-localizes with it in the Lewy bodies,
influencing α-Syn pathology in Parkinson's disease (PD). However, whether these …

Brain-derived neurotrophic factor (BDNF) has multiple roles in the central nervous system
(CNS), including maintaining cell survival and regulation of synaptic function. In CNS …

The GABAergic deficit hypothesis of major depressive disorders (MDDs) posits that reduced
γ-aminobutyric acid (GABA) concentration in brain, impaired function of GABAergic …

Activity-dependent gene transcription, including that of the brain-derived neurotrophic factor
(Bdnf) gene, has been implicated in various cognitive functions. We previously …