Inflammation: the link between comorbidities, genetics, and Alzheimer's disease

EA Newcombe, J Camats-Perna, ML Silva… - Journal of …, 2018 - Springer
Alzheimer's disease (AD) is a neurodegenerative disorder, most cases of which lack a clear
causative event. This has made the disease difficult to characterize and, thus, diagnose …

Inflammation and neuroprotection in traumatic brain injury

KN Corps, TL Roth, DB McGavern - JAMA neurology, 2015 - jamanetwork.com
Importance Traumatic brain injury (TBI) is a significant public health concern that affects
individuals in all demographics. With increasing interest in the medical and public …

Long-term consequences of traumatic brain injury: current status of potential mechanisms of injury and neurological outcomes

HM Bramlett, WD Dietrich - Journal of neurotrauma, 2015 - liebertpub.com
Traumatic brain injury (TBI) is a significant clinical problem with few therapeutic interventions
successfully translated to the clinic. Increased importance on the progressive, long-term …

Pathophysiology associated with traumatic brain injury: current treatments and potential novel therapeutics

ML Pearn, IR Niesman, J Egawa, A Sawada… - Cellular and molecular …, 2017 - Springer
Traumatic brain injury (TBI) is one of the leading causes of death of young people in the
developed world. In the United States alone, 1.7 million traumatic events occur annually …

[HTML][HTML] MSC-derived exosomes promote recovery from traumatic brain injury via microglia/macrophages in rat

Y Chen, J Li, B Ma, N Li, S Wang, Z Sun, C Xue… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in young individuals
worldwide. There is currently no effective clinical treatment for TBI, but mesenchymal stem …

Neuroinflammation in animal models of traumatic brain injury

CC Chiu, YE Liao, LY Yang, JY Wang… - Journal of neuroscience …, 2016 - Elsevier
Traumatic brain injury (TBI) is a leading cause of mortality and morbidity worldwide.
Neuroinflammation is prominent in the short and long-term consequences of neuronal …

Inflammatory reaction after traumatic brain injury: therapeutic potential of targeting cell–cell communication by chemokines

S Gyoneva, RM Ransohoff - Trends in pharmacological sciences, 2015 - cell.com
Traumatic brain injury (TBI) affects millions of people worldwide every year. The primary
impact initiates the secretion of pro-and anti-inflammatory factors, subsequent recruitment of …

Current understanding of neuroinflammation after traumatic brain injury and cell-based therapeutic opportunities

Y Xiong, A Mahmood, M Chopp - Chinese Journal of Traumatology, 2018 - mednexus.org
Traumatic brain injury (TBI) remains a major cause of death and disability worldwide.
Increasing evidence indicates that TBI is an important risk factor for neurodegenerative …

Emerging roles for the immune system in traumatic brain injury

CA McKee, JR Lukens - Frontiers in immunology, 2016 - frontiersin.org
Traumatic brain injury (TBI) affects an ever-growing population of all ages with long-term
consequences on health and cognition. Many of the issues that TBI patients face are thought …

The complexity of neuroinflammation consequent to traumatic brain injury: from research evidence to potential treatments

MC Morganti-Kossmann, BD Semple, SC Hellewell… - Acta …, 2019 - Springer
This review recounts the definitions and research evidence supporting the multifaceted roles
of neuroinflammation in the injured brain following trauma. We summarise the literature …