Growth factor engineering strategies for regenerative medicine applications

X Ren, M Zhao, B Lash, MM Martino… - … in bioengineering and …, 2020 - frontiersin.org
Growth factors are critical molecules for tissue repair and regeneration. Therefore,
recombinant growth factors have raised a lot of hope for regenerative medicine applications …

Bone grafts and their substitutes

Y Fillingham, J Jacobs - The bone & joint journal, 2016 - boneandjoint.org.uk
The continual cycle of bone formation and resorption is carried out by osteoblasts,
osteocytes, and osteoclasts under the direction of the bone-signaling pathway. In certain …

Materials science and design principles of growth factor delivery systems in tissue engineering and regenerative medicine

R Subbiah, RE Guldberg - Advanced healthcare materials, 2019 - Wiley Online Library
Growth factors (GFs) are signaling molecules that direct cell development by providing
biochemical cues for stem cell proliferation, migration, and differentiation. GFs play a key …

Цитокины в патогенезе и лечении заболеваний человека

АС Симбирцев - 2018 - elibrary.ru
В монографии приведены сведения по роли цитокинов в регуляции физиологических
процессов, защитных реакций организма и в патогенезе иммунопатологических …

The brown fat secretome: metabolic functions beyond thermogenesis

GX Wang, XY Zhao, JD Lin - Trends in Endocrinology & Metabolism, 2015 - cell.com
Brown fat is highly active in fuel oxidation and dissipates chemical energy through
uncoupling protein (UCP) 1-mediated heat production. Activation of brown fat leads to …

Retinal and choroidal angiogenesis: a review of new targets

T Cabral, LGM Mello, LH Lima, J Polido… - International journal of …, 2017 - Springer
Retinal and choroidal neovascularization are a major cause of significant visual impairment,
worldwide. Understanding the various factors involved in the accompanying …

The incorporation of zinc into hydroxyapatite and its influence on the cellular response to biomaterials: a systematic review

J Dornelas, G Dornelas, A Rossi, A Piattelli… - Journal of Functional …, 2024 - mdpi.com
Zinc is known for its role in enhancing bone metabolism, cell proliferation, and tissue
regeneration. Several studies proposed the incorporation of zinc into hydroxyapatite (HA) to …

Translating the role of osteogenic-angiogenic coupling in bone formation: Highly efficient chitosan-pDNA activated scaffolds can accelerate bone regeneration in …

RM Raftery, IM Castaño, G Chen, B Cavanagh… - Biomaterials, 2017 - Elsevier
The clinical translation of bioactive scaffolds for the treatment of large segmental bone
defects has remained a challenge due to safety and efficacy concerns as well as prohibitive …

Beyond the bone: Bone morphogenetic protein signaling in adipose tissue

AM Blázquez‐Medela, M Jumabay… - Obesity …, 2019 - Wiley Online Library
The bone morphogenetic proteins (BMPs) belong to the same superfamily as related to
transforming growth factor β (TGFβ), growth and differentiation factors (GDFs), and activins …

Bmp8a deletion leads to obesity through regulation of lipid metabolism and adipocyte differentiation

S Zhong, L Chen, X Li, X Wang, G Ji, C Sun… - Communications …, 2023 - nature.com
The role of bone morphogenetic proteins (BMPs) in regulating adipose has recently become
a field of interest. However, the underlying mechanism of this effect has not been elucidated …