Mechanisms of cell polarization
WJ Rappel, L Edelstein-Keshet - Current opinion in systems biology, 2017 - Elsevier
Cell polarization is a key step in the migration, development, and organization of eukaryotic
cells, both at the single cell and multicellular level. Research on the mechanisms that give …
cells, both at the single cell and multicellular level. Research on the mechanisms that give …
From damage response to action potentials: early evolution of neural and contractile modules in stem eukaryotes
Eukaryotic cells convert external stimuli into membrane depolarization, which in turn triggers
effector responses such as secretion and contraction. Here, we put forward an evolutionary …
effector responses such as secretion and contraction. Here, we put forward an evolutionary …
Altering the threshold of an excitable signal transduction network changes cell migratory modes
The diverse migratory modes displayed by different cell types are generally believed to be
idiosyncratic. Here we show that the migratory behaviour of Dictyostelium was switched from …
idiosyncratic. Here we show that the migratory behaviour of Dictyostelium was switched from …
Non-Gaussianity, population heterogeneity, and transient superdiffusion in the spreading dynamics of amoeboid cells
What is the underlying diffusion process governing the spreading dynamics and search
strategies employed by amoeboid cells? Based on the statistical analysis of experimental …
strategies employed by amoeboid cells? Based on the statistical analysis of experimental …
Tunable 3D hydrogel microchannel networks to study confined mammalian cell migration
Cells adapt and move due to chemical, physical, and mechanical cues from their
microenvironment. It is therefore important to create materials that mimic human tissue …
microenvironment. It is therefore important to create materials that mimic human tissue …
Phase-field model of cellular migration: Three-dimensional simulations in fibrous networks
Cell motion plays a key role in many biological processes. Computational models are
gaining momentum as a tool that allows a quantitative understanding of the main biological …
gaining momentum as a tool that allows a quantitative understanding of the main biological …
Modeling random crawling, membrane deformation and intracellular polarity of motile amoeboid cells
Amoeboid movement is one of the most widespread forms of cell motility that plays a key
role in numerous biological contexts. While many aspects of this process are well …
role in numerous biological contexts. While many aspects of this process are well …
Modeling contact inhibition of locomotion of colliding cells migrating on micropatterned substrates
DA Kulawiak, BA Camley… - PLoS computational …, 2016 - journals.plos.org
In cancer metastasis, embryonic development, and wound healing, cells can coordinate
their motion, leading to collective motility. To characterize these cell-cell interactions, which …
their motion, leading to collective motility. To characterize these cell-cell interactions, which …
Comparative mapping of crawling-cell morphodynamics in deep learning-based feature space
Navigation of fast migrating cells such as amoeba Dictyostelium and immune cells are tightly
associated with their morphologies that range from steady polarized forms that support high …
associated with their morphologies that range from steady polarized forms that support high …
Spontaneous transitions between amoeboid and keratocyte-like modes of migration
T Moldenhawer, E Moreno, D Schindler… - Frontiers in Cell and …, 2022 - frontiersin.org
The motility of adherent eukaryotic cells is driven by the dynamics of the actin cytoskeleton.
Despite the common force-generating actin machinery, different cell types often show …
Despite the common force-generating actin machinery, different cell types often show …