To preserve the integrity of their genome, bacteria rely on several genome maintenance
mechanisms that are co-ordinated with the cell cycle. All members of the Vibrio family have a …

Faithful vertical transmission of genetic information, especially of essential core genes, is a
prerequisite for bacterial survival. Hence, replication of all the replicons is tightly controlled …

Bacteria with multiple chromosomes represent up to 10% of all bacterial species. Unlike
eukaryotes, these bacteria use chromosome-specific initiators for their replication. In all …

For DNA replication initiation in Bacteria, replication initiation proteins bind to double-
stranded DNA (dsDNA) and interact with single-stranded DNA (ssDNA) at the replication …

Control of chromosome replication involves a common set of regulators in eukaryotes,
whereas bacteria with divided genomes use chromosome-specific regulators. How bacterial …

Replication of Vibrio cholerae chromosome 2 (Chr2) initiates when the Chr1 locus, crtS (C
hr2 r eplication t riggering s ite) duplicates. The site binds the Chr2 initiator, RctB, and the …

The initiation of chromosomal DNA replication starts at a replication origin, which in bacteria
is a discrete locus that contains DNA sequence motifs recognized by an initiator protein …

Highlights•All Vibrio species carry a genome divided in multiple chromosomes.•Replication
of the two V. cholerae chromosomes is temporally regulated and coupled to the cell …

In 1980s, the most genes involved in the bacterial flagellar function and formation had been
isolated, although many of their functions or roles were not clarified. Bacterial flagella are the …

Vibrio cholerae, the causative agent of the cholera disease, is commonly used as a model
organism for the study of bacteria with multipartite genomes. Its two chromosomes of …