Background: Non-invasive and patient-friendly nose-to-brain pathway is the best-suited
route for brain delivery of therapeutics as it bypasses the blood–brain barrier. The intranasal …

Background Polysaccharides acceded by the Food and Drug Administration are among the
most exploitable polymers for fabricating nasally applied vehicles containing therapeutically …

Modern nanostructures must fulfill a wide range of functions to be valuable, leading to the
combination of various nano-objects into hierarchical assemblies. Hybrid Nanoparticles …

Recent advances have been reported for needle-free local anesthesia in maxillary teeth by
administering a nasal spray of tetracaine (TTC) and oxymetazoline, without causing pain …

In recent decades, there has been an increased interest in the development of intranasal
delivery systems for active pharmaceutical ingredients (APIs) not only for treating local nasal …

Migraine is a disabling disease characterized by severe throbbing headaches. Patients
demand quick relief from this pain. The presence of the blood-brain barrier does not permit …

The oil of the Unani medicinal herb Baboona (Matricaria chamomilla) has shown potential in
the management of pain. However, predicaments such as poor skin penetration, skin …

The oral administration of the anti-inflammatory indomethacin (INDO) causes severe
gastrointestinal side effects, which are intensified in chronic inflammatory conditions when a …

Nanoemulsions (NEs) are thermodynamically unstable systems comprising at least two
immiscible liquid phases with diameters within the “nanometric” range, generally under 200 …

Objective (s): Migraine, a serious neurological disease that affects millions of people
worldwide, is one of the most considerable burdens on the healthcare system and has …