[HTML][HTML] Natural medicine in neuroprotection for ischemic stroke: Challenges and prospective
T Tao, M Liu, M Chen, Y Luo, C Wang, T Xu… - Pharmacology & …, 2020 - Elsevier
There is a growing interest in using natural medicines to treat stroke as the leading cause of
disability worldwide. Especially plant-derived natural medicines have multiple beneficial …
disability worldwide. Especially plant-derived natural medicines have multiple beneficial …
[HTML][HTML] Target identification of natural medicine with chemical proteomics approach: probe synthesis, target fishing and protein identification
Natural products are an important source of new drugs for the treatment of various diseases.
However, developing natural product-based new medicines through random moiety …
However, developing natural product-based new medicines through random moiety …
[HTML][HTML] Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1
Ferroptosis is a form of regulated cell death, characterized by excessive membrane lipid
peroxidation in an iron-and ROS-dependent manner. Celastrol, a natural bioactive …
peroxidation in an iron-and ROS-dependent manner. Celastrol, a natural bioactive …
[HTML][HTML] Celastrol induces ROS-mediated apoptosis via directly targeting peroxiredoxin-2 in gastric cancer cells
X Chen, Y Zhao, W Luo, S Chen, F Lin, X Zhang… - Theranostics, 2020 - ncbi.nlm.nih.gov
Background: Oxidative stress from elevated reactive oxygen species (ROS) has been
reported to induce cell apoptosis and may provide a means to target cancer cells. Celastrol …
reported to induce cell apoptosis and may provide a means to target cancer cells. Celastrol …
[HTML][HTML] Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1
H Xu, H Zhao, C Ding, D Jiang, Z Zhao, Y Li… - … and Targeted Therapy, 2023 - nature.com
As a terpenoids natural product isolated from the plant Thunder God Vine, Celastrol is
widely studied for its pharmacological activities, including anti-tumor activities. The clinical …
widely studied for its pharmacological activities, including anti-tumor activities. The clinical …
[HTML][HTML] Withania somnifera (L.) Dunal: opportunity for clinical repurposing in COVID-19 management
A Saggam, K Limgaokar, S Borse… - Frontiers in …, 2021 - frontiersin.org
As the COVID-19 pandemic is progressing, the therapeutic gaps in conventional
management have highlighted the need for the integration of traditional knowledge systems …
management have highlighted the need for the integration of traditional knowledge systems …
[HTML][HTML] Triptolide: reflections on two decades of research and prospects for the future
Covering: 2000 to 2020 Triptolide is a bioactive diterpene triepoxide isolated from
Tripterygium wilfordii Hook F, a traditional Chinese medicinal plant whose extracts have …
Tripterygium wilfordii Hook F, a traditional Chinese medicinal plant whose extracts have …
[HTML][HTML] A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F
Triptolide and celastrol are predominantly active natural products isolated from the
medicinal plant Tripterygium wilfordii Hook F. These compounds exhibit similar …
medicinal plant Tripterygium wilfordii Hook F. These compounds exhibit similar …
Targeting apoptosis and autophagy following spinal cord injury: Therapeutic approaches to polyphenols and candidate phytochemicals
Spinal cord injury (SCI) is a neurological disorder associated with the loss of sensory and
motor function. Understanding the precise dysregulated signaling pathways, especially …
motor function. Understanding the precise dysregulated signaling pathways, especially …
Triptolide: Medicinal chemistry, chemical biology and clinical progress
W Hou, B Liu, H Xu - European journal of medicinal chemistry, 2019 - Elsevier
In the past decades, triptolide has attracted considerable interests in the organic and
medicinal chemistry society owing to its intriguing structure features and promising multiple …
medicinal chemistry society owing to its intriguing structure features and promising multiple …