Importance Questions of whether and how cortical thickness (CTh) alterations differ over the
course of schizophrenia (SCZ) have yet to be resolved. Objective To characterize CTh …

Unlike neurologic conditions, such as brain tumors, dementia, and stroke, the neural
mechanisms for all psychiatric disorders remain unclear. A large body of research obtained …

Neurobiological heterogeneity in schizophrenia is poorly understood and confounds current
analyses. We investigated neuroanatomical subtypes in a multi-institutional multi-ethnic …

The long‐term benefit‐to‐risk ratio of sustained antipsychotic treatment for schizophrenia
has recently been questioned. In this paper, we critically examine the literature on the long …

Objective: Despite the multitude of longitudinal neuroimaging studies that have been
published, a basic question on the progressive brain loss in schizophrenia remains …

One important challenge in psychiatric research is to translate findings from brain imaging
research studies that identified brain alterations in patient groups into an accurate diagnosis …

Objective: Although brain changes in schizophrenia have been proposed to mirror those
found with advancing age, the trajectory of gray matter and white matter changes during the …

Background The current definitions of psychotic illness lack biological validity, motivating
alternative biomarker-driven disease entities. Building on experimental constructs—Biotypes …

Abstract Changes in brain volume are a common finding in Magnetic Resonance Imaging
(MRI) studies of people with psychosis and numerous longitudinal studies suggest that …

Disease heterogeneity is a significant obstacle to understanding pathological processes and
delivering precision diagnostics and treatment. Clustering methods have gained popularity …