During division, eukaryotic cells undergo a dramatic, complex and coordinated remodelling
of their cytoskeleton and membranes. For cell division to occur, chromosomes must be …

Cytokinesis mediates the physical separation of dividing cells after chromosome
segregation. In animal cell cytokinesis, a contractile ring, mainly composed of actin and …

Entry and progression through mitosis has traditionally been linked directly to the activity of
cyclin-dependent kinase 1 (Cdk1). In this study we utilized low doses of the Cdk1-specific …

PP2A-B55 is one of the major phosphatases regulating cell division. Despite its importance
for temporal control during mitotic exit, how B55 substrates are recognized and differentially …

Here, we will review the evidence showing that mitotic exit is initiated by regulated
proteolysis and then driven by the PPP family of phosphoserine/threonine phosphatases …

The accurate segregation of genetic material to daughter cells during mitosis depends on
the precise coordination and regulation of hundreds of proteins by dynamic phosphorylation …

Entry into mitosis is triggered by the activation of cyclin‐dependent kinase 1 (Cdk1). This
simple reaction rapidly and irreversibly sets the cell up for division. Even though the core …

The spindle assembly checkpoint (SAC) monitors correct attachment of chromosomes to
microtubules, an important safeguard mechanism ensuring faithful chromosome segregation …

The midbody is an organelle assembled at the intercellular bridge between the two daughter
cells at the end of mitosis. It controls the final separation of the daughter cells and has been …

Abstract Protein phosphatase 2A (PP2A) in complex with B55 regulatory subunits reverses
cyclin-dependent kinase 1 (Cdk1) phosphorylations at mitotic exit,,,,. Interestingly, threonine …