Goods and bads of the endocannabinoid system as a therapeutic target: Lessons learned after 30 years
The cannabis derivative marijuana is the most widely used recreational drug in the Western
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …
Cannabis-based products for chronic pain: a systematic review
MS McDonagh, BJ Morasco, J Wagner… - Annals of internal …, 2022 - acpjournals.org
Background: Contemporary data are needed about the utility of cannabinoids in chronic
pain. Purpose: To evaluate the benefits and harms of cannabinoids for chronic pain. Data …
pain. Purpose: To evaluate the benefits and harms of cannabinoids for chronic pain. Data …
Cannabis Bioactive Compound-Based Formulations: New Perspectives for the Management of Orofacial Pain
G Crescente, G Minervini, C Spagnuolo, S Moccia - Molecules, 2022 - mdpi.com
The management of orofacial pain to alleviate the quality of life of affected patients is
becoming increasingly challenging for scientific research and healthcare professionals …
becoming increasingly challenging for scientific research and healthcare professionals …
THC and CBD: Similarities and differences between siblings
N Stella - Neuron, 2023 - cell.com
Summary Δ 9-tetrahydrocannabinol (THC) and its sibling, cannabidiol (CBD), are produced
by the same Cannabis plant and have similar chemical structures but differ dramatically in …
by the same Cannabis plant and have similar chemical structures but differ dramatically in …
Systematic review and meta-analysis of cannabinoids, cannabis-based medicines, and endocannabinoid system modulators tested for antinociceptive effects in …
We report a systematic review and meta-analysis of studies that assessed the
antinociceptive efficacy of cannabinoids, cannabis-based medicines, and endocannabinoid …
antinociceptive efficacy of cannabinoids, cannabis-based medicines, and endocannabinoid …
Cannabidiol treatment in hand osteoarthritis and psoriatic arthritis: a randomized, double-blind, placebo-controlled trial
J Vela, L Dreyer, KK Petersen, L Arendt-Nielsen… - Pain, 2022 - journals.lww.com
Cannabidiol (CBD) is increasingly used as analgesic medication although the recent
International Association for the Study of Pain Presidential Task Force on cannabis and …
International Association for the Study of Pain Presidential Task Force on cannabis and …
Cannabis-based medicines and medical cannabis for chronic neuropathic pain
F Petzke, T Tölle, MA Fitzcharles, W Häuser - CNS drugs, 2022 - Springer
Neuropathic pain represents a broad category of pain syndromes that include a wide variety
of peripheral and central disorders. The overall prevalence of neuropathic pain in the …
of peripheral and central disorders. The overall prevalence of neuropathic pain in the …
Differential regulation of Cav3.2 and Cav2.2 calcium channels by CB1 receptors and cannabidiol
Background and Purpose Cannabinoids are a promising therapeutic avenue for chronic
pain. However, clinical trials often fail to report analgesic efficacy of cannabinoids. Inhibition …
pain. However, clinical trials often fail to report analgesic efficacy of cannabinoids. Inhibition …
Protective effect of berberine in diabetic nephropathy: a systematic review and meta-analysis revealing the mechanism of action
S Hu, J Wang, E Liu, X Zhang, J Xiang, W Li… - Pharmacological …, 2022 - Elsevier
Abstract Coptis Chinensis Franch is widely used in the treatment of diabetes, and berberine
is the primary bioactive component in it. Evidence from previous studies has shown that …
is the primary bioactive component in it. Evidence from previous studies has shown that …
Endocannabinoid-based therapies
D Piomelli, A Mabou Tagne - Annual Review of Pharmacology …, 2022 - annualreviews.org
The endocannabinoids are lipid-derived messengers that play a diversity of regulatory roles
in mammalian physiology. Dysfunctions in their activity have been implicated in various …
in mammalian physiology. Dysfunctions in their activity have been implicated in various …