Voltage‐gated calcium channels are essential players in many physiological processes in
excitable cells. There are three main subdivisions of calcium channel, defined by the pore …

The gabapentinoid drugs gabapentin and pregabalin are key front‐line therapies for various
neuropathies of peripheral and central origin. Originally designed as analogs of GABA, the …

T-type Ca2+ channels were originally called low-voltage-activated (LVA) channels because
they can be activated by small depolarizations of the plasma membrane. In many neurons …

The von Willebrand A (VWA) domain is a well-studied domain involved in cell adhesion, in
extracellular matrix proteins, and in integrin receptors. A number of human diseases arise …

Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …

Pregabalin (Lyrica™) is a new antiepileptic drug that is active in animal seizure models.
Pregabalin is approved in US and Europe for adjunctive therapy of partial seizures in adults …

Voltage-gated calcium channels consist of the main pore-forming α1 subunit, together,
except in the case of the T-type channels, with β and α2δ and sometimes γ subunits, which …

In this review, we examine what is known about the mechanism of action of the auxiliary α 2
δ subunits of voltage-gated Ca 2+(Ca v) channels. First, to provide some background on the …

Voltage-gated calcium (CaV) channels are ubiquitously expressed in various cell types
throughout the body. In principle, the molecular identity, biophysical profile, and …

The mouse mutant ducky, a model for absence epilepsy, is characterized by spike-wave
seizures and ataxia. The ducky gene was mapped previously to distal mouse chromosome …