Endothelial cells (ECs) are highly specialized across vascular beds. However, given their
interspersed anatomic distribution, comprehensive characterization of the molecular basis …

The pleiotropic benefits of statins in cardiovascular diseases that are independent of their
lipid-lowering effects have been well documented, but the underlying mechanisms remain …

The two principal cell types of importance for normal vessel wall physiology are smooth
muscle cells and endothelial cells. Much progress has been made over the past 20 years in …

Sepsis is a systemic inflammatory response to infections associated with organ failure that is
the most frequent cause of death in hospitalized patients. Exaggerated endothelial …

Together with mesangial cells, glomerular endothelial cells and the basement membrane,
podocytes constitute the glomerular filtration barrier (GFB) of the kidney. Podocytes play a …

Sepsis is a severe systemic inflammatory response to infection. Endothelial activation and
dysfunction play a critical role in the pathophysiology of sepsis and represent an important …

Etv2 is an essential transcriptional regulator of hematoendothelial lineages during
embryogenesis. Although Etv2 downstream targets have been identified, little is known …

Rationale Tie2 is predominantly expressed by endothelial cells and is involved in vascular
integrity control during sepsis. Changes in Tie2 expression during sepsis development may …

The human papillomavirus (HPV) is the etiologic agent of cervical cancer. In this study, we
provide evidence for the human Pygopus (hPygo) 2 gene as a cellular biomarker for HPV …

Background Several QTLs have been identified for major economically relevant traits in
livestock, such as growth and meat quality, revealing the complex genetic architecture of …