[HTML][HTML] The extracellular matrix and transforming growth factor-β1: Tale of a strained relationship
B Hinz - Matrix biology, 2015 - Elsevier
Physiological tissue repair aims at restoring the mechano-protective properties of the
extracellular matrix. Consequently, redundant regulatory mechanisms are in place ensuring …
extracellular matrix. Consequently, redundant regulatory mechanisms are in place ensuring …
Repurposing of histone deacetylase inhibitors: A promising strategy to combat pulmonary fibrosis promoted by TGF-β signalling in COVID-19 survivors
Abstract Coronavirus disease 2019 (COVID-19) has rapidly spread around the world
causing global public health emergency. In the last twenty years, we have witnessed several …
causing global public health emergency. In the last twenty years, we have witnessed several …
BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics
C Hiepen, J Jatzlau, S Hildebrandt, B Kampfrath… - PLoS …, 2019 - journals.plos.org
Balanced transforming growth factor-beta (TGFβ)/bone morphogenetic protein (BMP)-
signaling is essential for tissue formation and homeostasis. While gain in TGFβ signaling is …
signaling is essential for tissue formation and homeostasis. While gain in TGFβ signaling is …
Hypoxia induces stress fiber formation in adipocytes in the early stage of obesity
G Anvari, E Bellas - Scientific Reports, 2021 - nature.com
In obese adipose tissue (AT), hypertrophic expansion of adipocytes is not matched by new
vessel formation, leading to AT hypoxia. As a result, hypoxia inducible factor-1⍺(HIF-1⍺) …
vessel formation, leading to AT hypoxia. As a result, hypoxia inducible factor-1⍺(HIF-1⍺) …
[HTML][HTML] Eosinophils and tissue remodeling: relevance to airway disease
S Siddiqui, C Bachert, L Bjermer, KM Buchheit… - Journal of Allergy and …, 2023 - Elsevier
The ability of human tissue to reorganize and restore its existing structure underlies tissue
homeostasis in the healthy airways, but in disease can persist without normal resolution …
homeostasis in the healthy airways, but in disease can persist without normal resolution …
A role for estrogen in skin ageing and dermal biomechanics
HN Wilkinson, MJ Hardman - Mechanisms of Ageing and Development, 2021 - Elsevier
The skin is the body's primary defence against the external environment, preventing
infection and desiccation. Therefore, alterations to skin homeostasis, for example with skin …
infection and desiccation. Therefore, alterations to skin homeostasis, for example with skin …
Fibronectin as a multiregulatory molecule crucial in tumor matrisome: from structural and functional features to clinical practice in oncology
S Spada, A Tocci, F Di Modugno, P Nisticò - Journal of Experimental & …, 2021 - Springer
Deciphering extracellular matrix (ECM) composition and architecture may represent a novel
approach to identify diagnostic and therapeutic targets in cancer. Among the ECM …
approach to identify diagnostic and therapeutic targets in cancer. Among the ECM …
Nanoapproaches to modifying epigenetics of epithelial mesenchymal transition for treatment of pulmonary fibrosis
Idiopathic Pulmonary Fibrosis (IPF) is a chronically progressive interstitial lung that affects
over 3 M people worldwide and rising in incidence. With a median survival of 2–3 years, IPF …
over 3 M people worldwide and rising in incidence. With a median survival of 2–3 years, IPF …
[HTML][HTML] Matrix mechanics as regulatory factors and therapeutic targets in hepatic fibrosis
G Chen, B Xia, Q Fu, X Huang, F Wang… - International journal of …, 2019 - ncbi.nlm.nih.gov
The hallmark of liver fibrosis is excessive extracellular matrix (ECM) synthesis and
deposition that improve liver matrix remodeling and stiffening. Increased matrix stiffness is …
deposition that improve liver matrix remodeling and stiffening. Increased matrix stiffness is …
Animal models of glucocorticoid-induced glaucoma
Glucocorticoid (GC) therapy is widely used to treat a variety of inflammatory diseases and
conditions. While unmatched in their anti-inflammatory and immunosuppressive activities …
conditions. While unmatched in their anti-inflammatory and immunosuppressive activities …