Chronic kidney disease (CKD) is one of the fastest growing causes of death worldwide,
emphasizing the need to develop novel therapeutic approaches. CKD predisposes to acute …

Mitochondria are highly dynamic organelles of crucial importance to the proper functioning
of neuronal, cardiac and other cell types dependent upon aerobic efficiency. Mitochondrial …

Background: Myocardial ischemia-reperfusion (MI/R) injury is a significant clinical problem
without effective therapy. Unbiased omics approaches may reveal key MI/R mediators to …

A myriad of environmental and genetic factors, as well as the physiologic process of aging,
contribute to Alzheimer's disease (AD) pathology. Neuroinflammation is and has been a …

Alzheimer's disease (AD) is the most common neurodegenerative disorder to date, with no
curative or preventive therapy. Histopathological hallmarks of AD include deposition of β …

Alzheimer's disease (AD) is a persistent neuropathological stipulation manifested in the form
of neuronal/synapse demise, the formation of senile plaques, hyperphosphorylated tau …

Mitochondrial dysfunction has been implicated in the pathogenesis of Parkinson's disease
(PD) for several decades, and disturbed mitochondrial biogenesis (mitobiogenesis) was …

Background and purpose: Neurological diseases and injuries to the nervous system may
cause inadvertent damage to neuronal and synaptic structures. Such phenomenon would …

Insulin resistance (IR) is a fundamental pathogenic factor shared by a myriad of metabolic
disorders, including obesity and type 2 diabetes. The mechanism of IR is usually …

It is reported that the amyloid-β protein (Aβ)-induced impairments in synaptic plasticity
coincide with memory decline and dementia. Although Aβ-induced inhibition of hippocampal …