Survival of the African trypanosome within its mammalian hosts, and hence transmission
between hosts, relies upon antigenic variation, where stochastic changes in the composition …

Protozoan parasites colonize numerous metazoan hosts and insect vectors through their life
cycles, with the need to respond quickly and reversibly while encountering diverse and often …

Variant surface glycoprotein (VSG) coats bloodstream form Trypanosoma brucei parasites,
and monoallelic VSG expression underpins the antigenic variation necessary for …

Trypanosomes diverged from the main eukaryotic lineage about 600 million years ago, and
display some unusual genomic and epigenetic properties that provide valuable insight into …

One of the most powerful drivers of evolutionary change is the process of adaptation and
counter‐adaptation by interacting species (1). The so‐called “arms race” between parasites …

Introduction: Trypanosoma brucei uses antigenic variation to evade the host antibody
clearance by periodically changing its Variant Surface Glycoprotein (VSGs) coat. T. brucei …

Abstract The Molecular Parasitology conference was first held at the Marine Biological
laboratory, Woods Hole, USA 25 years ago. Since that first meeting, the conference has …

Survival of Trypanosoma brucei depends upon switches in its protective Variant Surface
Glycoprotein (VSG) coat by antigenic variation. VSG switching occurs by frequent …

African trypanosomes are lethal human and animal parasites that use antigenic variation for
evasion of host adaptive immunity. To facilitate antigenic variation, trypanosomes dedicate …

Unusually for a eukaryote, Trypanosoma brucei transcribes its variant surface glycoprotein
(VSG) gene expression sites (ESs) in a monoallelic fashion using RNA polymerase I (Pol I) …