[HTML][HTML] CD8+ T cells in HIV control, cure and prevention
HIV infection can be effectively treated by lifelong administration of combination antiretroviral
therapy, but an effective vaccine will likely be required to end the HIV epidemic. Although the …
therapy, but an effective vaccine will likely be required to end the HIV epidemic. Although the …
Human circulating and tissue-resident memory CD8+ T cells
Our current knowledge of human memory CD8+ T cells is derived largely from studies of the
intravascular space. However, emerging data are starting to challenge some of the dogmas …
intravascular space. However, emerging data are starting to challenge some of the dogmas …
[HTML][HTML] Single-cell multiomics reveals persistence of HIV-1 in expanded cytotoxic T cell clones
Understanding the drivers and markers of clonally expanding HIV-1-infected CD4+ T cells is
essential for HIV-1 eradication. We used single-cell ECCITE-seq, which captures surface …
essential for HIV-1 eradication. We used single-cell ECCITE-seq, which captures surface …
Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans
T cell exhaustion is an induced state of dysfunction that arises in response to chronic
infection and cancer. Exhausted CD8+ T cells acquire a distinct epigenetic state, but it is not …
infection and cancer. Exhausted CD8+ T cells acquire a distinct epigenetic state, but it is not …
Cytolytic CD8+ T cells infiltrate germinal centers to limit ongoing HIV replication in spontaneous controller lymph nodes
DR Collins, J Hitschfel, JM Urbach… - Science …, 2023 - science.org
Follicular CD8+ T cells (fCD8) mediate surveillance in lymph node (LN) germinal centers
against lymphotropic infections and cancers, but the precise mechanisms by which these …
against lymphotropic infections and cancers, but the precise mechanisms by which these …
[HTML][HTML] The identity of human tissue-emigrant CD8+ T cells
Lymphocyte migration is essential for adaptive immune surveillance. However, our current
understanding of this process is rudimentary, because most human studies have been …
understanding of this process is rudimentary, because most human studies have been …
The TLR7 agonist vesatolimod induced a modest delay in viral rebound in HIV controllers after cessation of antiretroviral therapy
D SenGupta, C Brinson, E DeJesus, A Mills… - Science translational …, 2021 - science.org
Toll-like receptor 7 (TLR7) agonists, in combination with other therapies, can induce
sustained control of simian-human immunodeficiency virus (SHIV) or simian …
sustained control of simian-human immunodeficiency virus (SHIV) or simian …
[HTML][HTML] Insights into persistent HIV-1 infection and functional cure: novel capabilities and strategies
TM Ta, S Malik, EM Anderson, AD Jones… - Frontiers in …, 2022 - frontiersin.org
Although HIV-1 replication can be efficiently suppressed to undetectable levels in peripheral
blood by combination antiretroviral therapy (cART), lifelong medication is still required in …
blood by combination antiretroviral therapy (cART), lifelong medication is still required in …
[HTML][HTML] Immunological approaches to HIV cure
Combination antiretroviral therapy (ART) to treat human immunodeficiency virus (HIV)
infection has proven remarkably successful–for those who can access and afford it–yet HIV …
infection has proven remarkably successful–for those who can access and afford it–yet HIV …
[HTML][HTML] TCF-1 regulates HIV-specific CD8+ T cell expansion capacity
Although many HIV cure strategies seek to expand HIV-specific CD8+ T cells to control the
virus, all are likely to fail if cellular exhaustion is not prevented. A loss in stem-like memory …
virus, all are likely to fail if cellular exhaustion is not prevented. A loss in stem-like memory …