Cardiovascular diseases (CVDs) are the leading cause of death worldwide and represent a
major problem of public health. Over the years, life expectancy has considerably increased …

A growing number of clinical and epidemiological studies support the hypothesis of a tight
correlation between type 2 diabetes mellitus (T2DM) and the development risk of …

Impaired healing leading to the formation of ulcerated wounds is a critical concern in
patients with diabetes. Abnormalities in extracellular matrix (ECM) production and …

The products of elastin degradation, namely elastin-derived peptides (EDPs), are detectable
in the cerebrospinal fluid of healthy individuals and in patients after ischemic stroke, and …

During vascular aging or in pathological conditions in humans, elastin is degraded and its
by-products, the elastin-derived peptides (EDPs), enter the blood circulation. EDPs may be …

Background Peritoneal dialysis (PD) patients experience accelerated arterial aging, which is
characterized by elastin degradation. Elastin-derived peptides (EDPs) are direct products of …

Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous skin condition. It
belongs to a group of skin and elastic fiber disorders. When it affects sun-exposed skin, it is …

Les fibres élastiques, composées d'élastine (90%) et de microfibrilles riches en fibrilline
(10%), sont les principaux composants extracellulaires qui confèrent aux artères leur …

Je tiens à remercier également les membres du jury pour avoir accepté d'évaluer ma thèse.
Merci au Docteur Ralf JOCKERS et au Docteur Muriel LAFFARGUE, rapporteurs, pour leur …

Cardiovascular disease remains the leading cause of death worldwide. Over the last
decade, arterial stiffening of conduit vessels has emerged as an independent risk factor for …