Summary The Cancer Genome Atlas (TCGA) has catalyzed systematic characterization of
diverse genomic alterations underlying human cancers. At this historic junction marking the …

Tumors display widespread transcriptome alterations, but the full repertoire of isoform-level
alternative splicing in cancer is unknown. We developed a long-read (LR) RNA sequencing …

The spread of cells from primary tumors toward distant tissues and organs, also known as
metastasis, is responsible for most cancer-associated deaths. The metastasis cascade …

Breast cancer is the most common malignancy in women and has a high incidence rate and
mortality. Abnormal regulation of gene expression plays an important role in breast cancer …

Ewing sarcomas (ES) are biologically aggressive tumors of bone and soft tissues for which
no cure is currently available. Most ES patients do not respond to chemotherapeutic …

Background Triple-negative breast cancer (TNBC) is the most heterogeneous and malignant
subtype of breast cancer (BC). TNBC is defined by the absence of expression of estrogen …

Triple-negative breast cancer (TNBC), although highly lethal, lacks validated therapeutic
targets. Here, we report that U2 snRNP-associated SURP motif-containing protein …

Background Ubiquitin-conjugating enzyme E2C (UBE2C) has been previously reported to
correlate with the malignant progression of various human cancers, however, the exact …

Global dysregulation of RNA splicing and imbalanced sphingolipid metabolism has
emerged as promoters of cancer cell transformation. Here, we present specific signature of …

The biological players involved in angiogenesis are only partially defined. Here, we report
that endothelial cells (ECs) express a novel isoform of the cell-surface adhesion molecule …