Extraintestinal manifestations of inflammatory bowel disease: current concepts, treatment, and implications for disease management

G Rogler, A Singh, A Kavanaugh, DT Rubin - Gastroenterology, 2021 - Elsevier
Inflammatory bowel diseases (IBDs) are systemic diseases that manifest not only in the gut
and gastrointestinal tract, but also in the extraintestinal organs in many patients. The quality …

Newer biologic and small-molecule therapies for inflammatory bowel disease

DC Baumgart, C Le Berre - New England Journal of Medicine, 2021 - Mass Medical Soc
Newer Biologic and Small-Molecule Therapies for IBD There is still no cure for inflammatory
bowel disease. This review covers newer treatments that reflect our understanding of the …

Extraintestinal manifestations in inflammatory bowel disease–epidemiology, genetics, and pathogenesis

T Greuter, SR Vavricka - Expert review of gastroenterology & …, 2019 - Taylor & Francis
Introduction: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder, primarily
of, but not restricted to the gut. Extraintestinal manifestations (EIMs) are frequently observed …

[HTML][HTML] Extraintestinal manifestations of inflammatory bowel disease

JS Levine, R Burakoff - Gastroenterology & hepatology, 2011 - ncbi.nlm.nih.gov
Extraintestinal manifestations of inflammatory bowel disease are prevalent in both ulcerative
colitis and Crohn's disease. The most common manifestations involve the musculoskeletal …

Gut immune cell trafficking: inter-organ communication and immune-mediated inflammation

S Zundler, C Günther, AE Kremer, MM Zaiss… - Nature Reviews …, 2023 - nature.com
Immune cell trafficking is a complex and tightly regulated process that is indispensable for
the body's fight against pathogens. However, it is also increasingly acknowledged that …

Pediatric inflammatory bowel disease

M Bouhuys, WS Lexmond, PF van Rheenen - Pediatrics, 2023 - publications.aap.org
Inflammatory bowel diseases (IBDs) are chronic, immune-mediated disorders that include
Crohn's disease and ulcerative colitis. A pediatric onset of disease occurs in about 10% of …

ECCO guidelines on extraintestinal manifestations in inflammatory bowel disease

H Gordon, J Burisch, P Ellul, K Karmiris… - Journal of Crohn's …, 2024 - academic.oup.com
This is the second European Crohn's and Colitis Organisation [ECCO] evidence-based
consensus on extraintestinal manifestations [EIMs] of inflammatory bowel disease [IBD] and …

Emerging treatment options for extraintestinal manifestations in IBD

T Greuter, F Rieder, T Kucharzik, L Peyrin-Biroulet… - Gut, 2021 - gut.bmj.com
Extraintestinal manifestations (EIMs) are frequently observed in IBDs and contribute
considerably to morbidity and mortality. They have long been considered a difficult to treat …

Management of non-response and loss of response to anti-tumor necrosis factor therapy in inflammatory bowel disease

J Marsal, M Barreiro-de Acosta, I Blumenstein… - Frontiers in …, 2022 - frontiersin.org
Anti-tumor necrosis factor (anti-TNF) therapy has been successfully used as first-line
biologic treatment for moderate-to-severe inflammatory bowel disease (IBD), in both “step …

Current insights on the roles of gut microbiota in inflammatory bowel disease-associated extra-intestinal manifestations: Pathophysiology and therapeutic targets

Y Tie, Y Huang, R Chen, L Li, M Chen, S Zhang - Gut Microbes, 2023 - Taylor & Francis
Inflammatory bowel disease (IBD) is a chronic, recurrent inflammatory disease of the
gastrointestinal tract. In addition to digestive symptoms, patients with IBD may also develop …