R-loops are three-stranded structures that harbour an RNA–DNA hybrid and frequently form
during transcription. R-loop misregulation is associated with DNA damage, transcription …

Cellular senescence is a persistently hypoproliferative state with diverse stressors in a
specific aging microenvironment. Senescent cells have a double‐edged sword effect: they …

Ageing is a complex biological process in which a gradual decline in physiological fitness
increases susceptibility to diseases such as neurodegenerative disorders and cancer …

Maintenance of a minimal telomere length is essential to prevent cellular senescence. When
critically short telomeres arise in the absence of telomerase, they can be repaired by …

Genome replication involves dealing with obstacles that can result from DNA damage but
also from chromatin alterations, topological stress, tightly bound proteins or non-B DNA …

Telomeres—repeated, noncoding nucleotide motifs and associated proteins that are found
at the ends of eukaryotic chromosomes—mediate genome stability and determine cellular …

Background: Long-non-coding RNAs (lncRNAs), RNA molecules longer than 200
nucleotides, have been involved in several biological processes and in a growing number of …

Long non-coding RNAs (lncRNA), a class of non-coding RNA molecules recently identified
largely due to the efforts of FANTOM, and later GENCODE and ENCODE consortia, have …

While global chromatin conformation studies are emerging, very little is known about the
chromatin conformation of human telomeres. Most studies have focused on the role of …

The finding that transcription occurs at chromosome ends has opened new fields of study on
the roles of telomeric transcripts in chromosome end maintenance and genome stability …