The active role of pericytes during neuroinflammation in the adult brain
F Medina-Flores, G Hurtado-Alvarado, MA Deli… - Cellular and Molecular …, 2023 - Springer
Microvessels in the central nervous system (CNS) have one of the highest populations of
pericytes, indicating their crucial role in maintaining homeostasis. Pericytes are …
pericytes, indicating their crucial role in maintaining homeostasis. Pericytes are …
Transport studies using blood-brain barrier in vitro models: A critical review and guidelines
AR Santa-Maria, M Heymans, FR Walter… - … and Pathology of the …, 2020 - Springer
Permeation is one of the most evaluated parameters using preclinical in vitro blood-brain
barrier models, as it has long been considered to be one of the major factors influencing …
barrier models, as it has long been considered to be one of the major factors influencing …
Group 1 metabotropic glutamate receptors trigger glutamate-induced intracellular Ca2+ signals and nitric oxide release in human brain microvascular endothelial …
Neurovascular coupling (NVC) is the mechanism whereby an increase in neuronal activity
causes an increase in local cerebral blood flow (CBF) to ensure local supply of oxygen and …
causes an increase in local cerebral blood flow (CBF) to ensure local supply of oxygen and …
The effects of Vitis vinifera L. phenolic compounds on a blood-brain barrier culture model: Expression of leptin receptors and protection against cytokine-induced …
Ethnopharmacological relevance The medicinal properties of grapes (Vitis vinifera L.) are
well known since ancient times. Ethnobotanical grape preparations, like the Ayurvedic …
well known since ancient times. Ethnobotanical grape preparations, like the Ayurvedic …
In vitro models of the blood-brain barrier
W Neuhaus - Organotypic Models in Drug Development, 2021 - Springer
Abstract Knowledge about the transport of active compounds across the blood-brain barrier
is of essential importance for drug development. Systemically applied drugs for the central …
is of essential importance for drug development. Systemically applied drugs for the central …
Unveiling the crucial role of betaine: Modulation of GABA homeostasis via SLC6A1 transporter (GAT1)
M Bhatt, E Lazzarin, AS Alberto-Silva… - Cellular and Molecular …, 2024 - Springer
Betaine is an endogenous osmolyte that exhibits therapeutic potential by mitigating various
neurological disorders. However, the underlying cellular and molecular mechanisms …
neurological disorders. However, the underlying cellular and molecular mechanisms …
Natural Products as an Alternative Therapy for Brain Tumors: From Bench To Bedside
S Kumar, M Kumar, A Bijalwan, S Sharma… - Handbook of Oxidative …, 2022 - Springer
Incremental elevation in the trends of a brain tumor in recent years accounts for 5% adult
population, whereas the number exceeds 70% in the case of children. Evidence reveals an …
population, whereas the number exceeds 70% in the case of children. Evidence reveals an …
In vitro models of CNS barriers
In vitro models of the blood-brain barrier provide valuable mechanistic information and
useful assay systems for drug discovery and delivery. However, it is important to take into …
useful assay systems for drug discovery and delivery. However, it is important to take into …