Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms

PD Cani, C Depommier, M Derrien, A Everard… - Nature Reviews …, 2022 - nature.com
Ever since Akkermansia muciniphila was discovered and characterized two decades ago,
numerous studies have shown that the lack or decreased abundance of this commensal …

Role of the gut microbiome in chronic diseases: a narrative review

A Vijay, AM Valdes - European journal of clinical nutrition, 2022 - nature.com
The gut microbiome, ie, the community of bacteria and other microorganisms living in the
human gut, has been implicated both directly and indirectly (mediating the effects of diet) on …

[HTML][HTML] Role and mechanism of gut microbiota in human disease

Y Chen, J Zhou, L Wang - Frontiers in cellular and infection …, 2021 - frontiersin.org
The human gut microbiome is a huge microbial community that plays an irreplaceable role
in human life. With the further development of research, the influence of intestinal flora on …

Gut microbiota and cardiovascular disease

M Witkowski, TL Weeks, SL Hazen - Circulation research, 2020 - Am Heart Assoc
Fecal microbial community changes are associated with numerous disease states, including
cardiovascular disease (CVD). However, such data are merely associative. A causal …

Dietary lipids, gut microbiota and lipid metabolism

M Schoeler, R Caesar - Reviews in endocrine and metabolic disorders, 2019 - Springer
The gut microbiota is a central regulator of host metabolism. The composition and function of
the gut microbiota is dynamic and affected by diet properties such as the amount and …

Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study

C Depommier, A Everard, C Druart, H Plovier… - Nature medicine, 2019 - nature.com
Metabolic syndrome is characterized by a constellation of comorbidities that predispose
individuals to an increased risk of developing cardiovascular pathologies as well as type 2 …

Akkermansia muciniphila alleviates dextran sulfate sodium (DSS)-induced acute colitis by NLRP3 activation

S Qu, L Fan, Y Qi, C Xu, Y Hu, S Chen, W Liu… - Microbiology …, 2021 - Am Soc Microbiol
Akkermansia muciniphila has been proved to play a crucial role in the progression of colitis,
but its underlying mechanism remains inconclusive. In this study, we aim to investigate the …

The gut microbiome: Relationships with disease and opportunities for therapy

J Durack, SV Lynch - Journal of experimental medicine, 2019 - rupress.org
Over the past decade, our view of human-associated microbes has expanded beyond that of
a few species toward an appreciation of the diverse and niche-specialized microbial …

Akkermansia muciniphila is a promising probiotic

T Zhang, Q Li, L Cheng, H Buch… - Microbial …, 2019 - Wiley Online Library
Summary Akkermansia muciniphila (A. muciniphila), an intestinal symbiont colonizing in the
mucosal layer, is considered to be a promising candidate as probiotics. A. muciniphila is …

Function of Akkermansia muciniphila in Obesity: Interactions With Lipid Metabolism, Immune Response and Gut Systems

Y Xu, N Wang, HY Tan, S Li, C Zhang… - Frontiers in …, 2020 - frontiersin.org
Obesity and its metabolic syndrome, including liver disorders and type 2 diabetes, are a
worldwide epidemic and are intimately linked to diet. The gut microbiota interaction has …