Abstract Non-enzymatic chitinase-3 like-protein-1 (CHI3L1) belongs to glycoside hydrolase
family 18. It binds to chitin, heparin, and hyaluronic acid, and is regulated by extracellular …

Chitinase-like proteins (CLPs) are lectins combining properties of cytokines and growth
factors. Human CLPs include YKL-40, YKL-39 and SI-CLP that are secreted by cancer cells …

Abstract Cancer-Associated Fibroblasts (CAFs) are the most prominent stromal cell type in
breast tumors. CAFs promote tumor growth and metastasis by multiple mechanisms …

Inflammation plays a vital role at different stages of tumor progression. The development of
tumors is affected by inflammatory mediators produced by the tumor and the host. YKL …

The classical central macrophage found in erythroblastic islands plays an important role in
erythroblast differentiation, proliferation and enucleation in the bone marrow. Convenient …

GM-CSF is required for alveolar macrophage (AM) development shortly after birth and for
maintenance of AM functions throughout life, whereas M-CSF is broadly important for …

Chitinase-3-like protein 1 (CHI3L1), a chitinase-like protein family member, is a secreted
glycoprotein that mediates macrophage polarization, inflammation, apoptosis, angiogenesis …

Numerous studies have investigated the prognostic role of YKL-40 in breast cancer, but
yielded inconsistent results. To derive a more precise evaluation, relevant publications …

Chitinase-like proteins (CLPs) are members of the family 18 glycosyl hydrolases, which
include chitinases and the enzymatically inactive CLPs. A mutation in the enzyme's catalytic …

Abstract Background Chitinase-like proteins (CLPs) play a key role in immunosuppression
under inflammatory conditions such as cancer. CLPs are enzymatically inactive and become …