Specific bile acids and their signaling pathways play important roles in control of
(cholesterol) metabolism. Deeper insight into the interactions between endogenous (ie, bile …

Rapamycin, an inhibitor of m TOR kinase, increased median lifespan of genetically
heterogeneous mice by 23%(males) to 26%(females) when tested at a dose threefold higher …

To follow‐up on our previous report that acarbose (ACA), a drug that blocks postprandial
glucose spikes, increases mouse lifespan, we studied ACA at three doses: 400, 1,000 (the …

Bile acids, their physiology and metabolism, their role in carcinogenesis and other major
human diseases are recently undergoing significant progress. Starting in 1999 when the …

In chronologically aging yeast, longevity can be extended by administering a caloric
restriction (CR) diet or some small molecules. These life-extending interventions target the …

Calorie restriction (CR) may extend longevity by modulating the mechanisms involved in
aging. Different hypotheses have been proposed for its main mode of action. We quantified …

Calorie restriction (CR) remains the most robust metabolic intervention to extend lifespan
and improve healthspan in several species. Using global and targeted mass spectrometry …

Bile acids (BAs) play important roles in physiological functions, including the homeostasis of
cholesterol and lipids and as ligands for G protein-coupled receptors (GPCRs). With the …

Bile acids are cholesterol-derived bioactive lipids that play essential roles in the
maintenance of a heathy lifespan. These amphipathic molecules with detergent-like …

Limited energy intake may result in the down-regulation of cellular defense mechanisms, or
if maintained, result in trade-offs with other physiological systems. To examine this, juvenile …