Targeting therapy for prostate cancer by pharmaceutical and clinical pharmaceutical strategies

W Sun, Y Deng, M Zhao, Y Jiang, J Gou, Y Wang… - Journal of Controlled …, 2021 - Elsevier
For the past few years, nanotechnology has provided a lot of new treatment opportunities for
prostate cancer patients, and brilliant achievements have been acquired indeed. It not only …

[HTML][HTML] Advances in structure-based drug design targeting membrane protein markers in prostate cancer

JP Batista-Silva, D Gomes, SF Sousa, Â Sousa… - Drug Discovery …, 2024 - Elsevier
Prostate cancer (PCa) is one of the leading cancers in men and the lack of suitable
biomarkers or their modulators results in poor prognosis. Membrane proteins (MPs) have a …

Genetically-engineered anti-PSMA exosome mimetics targeting advanced prostate cancer in vitro and in vivo

M Severic, G Ma, SGT Pereira, A Ruiz… - Journal of Controlled …, 2021 - Elsevier
The present work describes the engineering of anti-PSMA peptide-decorated exosome
mimetics (EMs) targeting advanced prostate cancer (PC). The targeted EMs were produced …

Synthesis and biological evaluation of PSMA ligands with aromatic residues and fluorescent conjugates based on them

AE Machulkin, RR Shafikov… - Journal of Medicinal …, 2021 - ACS Publications
Prostate-specific membrane antigen (PSMA), also known as glutamate carboxypeptidase II
(GCPII), is a suitable target for specific delivery of antitumor drugs and diagnostic agents due …

PSMA-targeted small-molecule docetaxel conjugate: Synthesis and preclinical evaluation

AE Machulkin, AA Uspenskaya, NY Zyk… - European Journal of …, 2022 - Elsevier
Prostate cancer is one of the most commonly diagnosed men's cancers and remains one of
the leading causes of cancer death. The development of approaches to the treatment of this …

A prostate-specific membrane antigen (PSMA)-targeted prodrug with a favorable in vivo toxicity profile

S Boinapally, HH Ahn, B Cheng, M Brummet, H Nam… - Scientific reports, 2021 - nature.com
Prostate-specific membrane antigen (PSMA) is a promising target for the treatment of
advanced prostate cancer (PC) and various solid tumors. Although PSMA-targeted …

Synthesis, 123I-Radiolabeling Optimization, and Initial Preclinical Evaluation of Novel Urea-Based PSMA Inhibitors with a Tributylstannyl Prosthetic Group in Their …

LA Hasnowo, MS Larkina, E Plotnikov… - International Journal of …, 2023 - mdpi.com
Prostate-specific membrane antigen (PSMA) has been identified as a target for the
development of theranostic agents. In our current work, we describe the design and …

[HTML][HTML] A novel dextran-based dual drug conjugate targeted tumors with high biodistribution ratio of tumors to Normal tissues

J Liu, N Zhang, J Wu, P Dong, H Lv… - International Journal …, 2022 - ncbi.nlm.nih.gov
Purpose Most chemotherapeutic agents possess poor water solubility and show more
significant accumulations in normal tissues than in tumor tissues, resulting in serious side …

Polypeptide-based molecular platform and its docetaxel/sulfo-Cy5-containing conjugate for targeted delivery to prostate specific membrane antigen

SA Petrov, AE Machulkin, AA Uspenskaya, NY Zyk… - Molecules, 2020 - mdpi.com
A strategy for stereoselective synthesis of molecular platform for targeted delivery of bimodal
therapeutic or theranostic agents to the prostate-specific membrane antigen (PSMA) …

J591 functionalized paclitaxel-loaded PLGA nanoparticles successfully inhibited PSMA overexpressing LNCaP cells

I Ehsan, L Kumari, R Sen, A Al Hoque… - Journal of Drug Delivery …, 2022 - Elsevier
To evaluate the chemotherapeutic efficacy of J591 fabricated poly (d, l)-lactic-co-glycolic
acid (PLGA) nanoparticles containing paclitaxel (Ab-PTX-NP) in vitro in PSMA (prostate …