GABAergic inhibition shapes the connectivity, activity and plasticity of the brain. A series of
exciting new discoveries provides compelling evidence that disruptions in a number of key …

In the 50 years since Andreas Rett first described the syndrome that came to bear his name,
and is now known to be caused by a mutation in the methyl-CpG-binding protein 2 (MECP2) …

This review describes recent research in pediatric sleep disorders associated with
neurodevelopmental disabilities (NDDs) and their treatment. NDDs affect more than 2% of …

Rett Syndrome (RTT) is an autism spectrum disorder caused by mutations in the X-linked
gene encoding methyl-CpG binding protein 2 (MeCP2). In order to map the neuroanatomic …

Rare diseases are very difficult to study mechanistically and to develop therapies for
because of the scarcity of patients. Here, the rare neuro-metabolic disorder Rett syndrome …

Rett syndrome (RTT, MIM# 312750) is a neurodevelopmental disorder that is classified as
an autism spectrum disorder. Clinically, RTT is characterized by psychomotor regression …

The interaction between epilepsy and sleep is thoroughly studied and is very complex. This
review focuses on prevalence, impact on quality of life and effects of treatment of sleep …

The onset of monophasic sleep, in which napping ceases and sleep consolidates into a
single night period, is a key developmental milestone of childhood. Yet to date, there is little …

This study provides the first meta-analysis of the purported differences in sleep time and
sleep quality between people with and without intellectual disabilities. Twenty-one papers …

Rett Syndrome (RTT) is a rare and severe X-linked developmental brain disorder that occurs
primarily in females, with a ratio of 1: 10.000. De novo mutations in the Methyl-CpG Binding …