Sulfation is a dynamic and complex posttranslational modification process. It can occur at
various positions within the glycosaminoglycan (GAG) backbone and modulates …

From an evolutionary perspective keratan sulfate (KS) is the newest glycosaminoglycan
(GAG) but the least understood. KS is a sophisticated molecule with a diverse structure, and …

Activation of the cyclic guanosine monophosphate (GMP)-AMP (cGAMP) sensor STING
requires its translocation from the endoplasmic reticulum to the Golgi apparatus and …

While it is expected for gene length to be associated with factors such as intron number and
evolutionary conservation, we are yet to understand the connections between gene length …

Oceans are a vast source of natural substances. In them, we find various compounds with
wide biotechnological and biomedical applicabilities. The exploitation of the sea as a …

The characteristic molecular composition of the different glycosaminoglycans (GAGs) is
related to their role as structural components and regulators of a multitude of functions of …

This chapter focuses on the structure, biosynthesis, and general biology of proteoglycans.
Topics include a description of the major families of proteoglycans, their characteristic …

The extracellular matrix (ECM) of the trabecular meshwork (TM) is thought to be important in
regulating intraocular pressure (IOP) in both normal and glaucomatous eyes. IOP is …

Proteoglycans (PGs) are glycosylated proteins of biological importance at cell surfaces, in
the extracellular matrix, and in the circulation. PGs are produced and modified by …

Chondroitin sulfate and dermatan sulfate are synthesized as galactosaminoglycan polymers
containing N‐acetylgalactosmine alternating with glucuronic acid. The sugar residues are …