[HTML][HTML] Novel directed enzyme prodrug therapy for cancer treatment based on 2′-deoxyribosyltransferase-conjugated magnetic nanoparticles
Directed enzyme prodrug therapy (DEPT) strategies show promise in mitigating
chemotherapy side effects during cancer treatment. Among these, the use of immobilized …
chemotherapy side effects during cancer treatment. Among these, the use of immobilized …
Non‐canonical nucleosides: Biomimetic triphosphorylation, incorporation into mRNA and effects on translation and structure
Recent advances in mRNA therapeutics demand efficient toolkits for the incorporation of
nucleoside analogues into mRNA suitable for downstream applications. Herein, we report …
nucleoside analogues into mRNA suitable for downstream applications. Herein, we report …
Chemo-enzymatic production of base-modified ATP analogues for polyadenylation of RNA
RM Mitton-Fry, J Eschenbach, H Schepers… - Chemical …, 2024 - pubs.rsc.org
Base-modified adenosine-5′-triphosphate (ATP) analogues are highly sought after as
building blocks for mRNAs and non-coding RNAs, for genetic code expansion or as …
building blocks for mRNAs and non-coding RNAs, for genetic code expansion or as …
Broadening the Substrate Scope of a Polyphosphate Kinase for Canonical and Non‐Canonical Nucleotides
T Querengässer, J Wenzlaff, C Loderer - ChemCatChem, 2024 - Wiley Online Library
Polyphosphate kinases (PPKs) are valuable biocatalysts for ATP cofactor regeneration as
well as for the phosphorylation of non‐canonical nucleotides. The versatility of PPKs in the …
well as for the phosphorylation of non‐canonical nucleotides. The versatility of PPKs in the …
Structural Insights into Broad-Range Polyphosphate Kinase 2 II Enzymes Applicable for Pyrimidine Nucleoside Diphosphate Synthesis
M Kuge, M Keppler, F Friedrich, R Saleem-Batcha… - bioRxiv, 2024 - biorxiv.org
Polyphosphate kinases (PPK) play crucial roles in various biological processes, including
energy storage and stress responses, through their interaction with inorganic polyphosphate …
energy storage and stress responses, through their interaction with inorganic polyphosphate …